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. 1997 Feb;6(1):64–68. doi: 10.1080/09629359791956

Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes

T Abiko 1,✉, H Sekino 1
PMCID: PMC2365843  PMID: 18472836

Abstract

Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that [1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abiko T., Sekino H. Deacetyl-thymosin beta 4: synthesis and effect on the impaired peripheral T-cell subsets in patients with chronic renal failure. Chem Pharm Bull (Tokyo) 1984 Nov;32(11):4497–4505. doi: 10.1248/cpb.32.4497. [DOI] [PubMed] [Google Scholar]
  2. Abiko T., Sekino H. Synthesis of a new biological response modifier thyrnosin beta(4) analogue and its restorative effect on depressed. Mediators Inflamm. 1992;1(2):113–119. doi: 10.1155/S096293519200019X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Abiko T., Sekino H. Synthesis of calf thymosin beta 4 fragment 16-38 and its effect on the impaired blastogenic response of T-lymphocytes of a uremic patient with pneumonia. Chem Pharm Bull (Tokyo) 1987 Sep;35(9):3757–3765. doi: 10.1248/cpb.35.3757. [DOI] [PubMed] [Google Scholar]
  4. Abiko T., Sekino H. Synthesis of six common amino acid sequence fragments of thymosins beta 4, beta 8 and beta 9 and determination of their effects on the low E-rosette forming cells of lupus nephritis patients. Chem Pharm Bull (Tokyo) 1984 Jan;32(1):228–236. doi: 10.1248/cpb.32.228. [DOI] [PubMed] [Google Scholar]
  5. Dobbelstein H. Immune system to uremia. Nephron. 1976;17(6):409–414. doi: 10.1159/000180749. [DOI] [PubMed] [Google Scholar]
  6. Low T. L., Goldstein A. L. Chemical characterization of thymosin beta 4. J Biol Chem. 1982 Jan 25;257(2):1000–1006. [PubMed] [Google Scholar]
  7. Montgomerie J. Z., Kalmanson G. M., Guze L. B. Renal failure and infection. Medicine (Baltimore) 1968 Jan;47(1):1–32. doi: 10.1097/00005792-196801000-00001. [DOI] [PubMed] [Google Scholar]

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