Abstract
Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. Previous experiments have shown that it has strong antiinflammatory effects. To investigate the mechanism of anti-inflammatory effects of esculentoside A (EsA),[3H] arachidonic acid (AA) prelabelled murine macrophage and radioimmunoassay were used to test the effect of EsA on the total release of AA and prostaglandin E2 in culture supernatants. The results showed that EsA had no significant effect on the total release of AA from murine macrophages. EsA (2.5-10 μmol/l), from unstimulated murine peritoneal macrophages and rabbit synovial cells, could decrease the production of prostaglandin E2. In A23187 and LPS-treated macrophages and synovial cells, EsA (10 μmol/l) could significantly decrease the prostaglandin E2 production. These results confirmed that EsA exerted an inhibitory effect on prostaglandin E2 production from murine macrophages and rabbit synovial cells.
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Selected References
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- Colville-Nash P. R., Scott D. L. Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications. Ann Rheum Dis. 1992 Jul;51(7):919–925. doi: 10.1136/ard.51.7.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fang J., Zheng Q. Y. [Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages]. Yao Xue Xue Bao. 1991;26(10):721–724. [PubMed] [Google Scholar]
- Ju D. W., Zheng Q. Y., Wang H. B., Guan X. J., Fang J., Yi Y. H. [Inhibitory effects of esculentoside A on mouse macrophages and antibody production]. Yao Xue Xue Bao. 1994;29(4):252–255. [PubMed] [Google Scholar]