Abstract
To examine whether the resistance allele of the Fv-4 gene (the Fv-4r gene) is a dominant inhibitory-product-encoding gene which an be used to prevent the development of murine AIDS (MAIDS), bone marrow cells from BALB/c-Fv-4wr mice were transplanted into BALB/c mice and C57BL/6 mice infected with MAIDS virus. Almost all of the virus-infected BALB/c and C57BL/6 mice developed MAIDS within 4 months and died 2 or 3 months later. However, when the virus-infected mice were subjected to cobalt irradiation and then given an intravenous injection of 10(7) BALB/c-Fv-4wr mouse bone marrow cells, the recipient mice survived much longer than the untreated mice, which suggests that the Fv-4 gene is a dominant inhibitory gene that is potentially useful in gene therapy of MAIDS.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baltimore D. Gene therapy. Intracellular immunization. Nature. 1988 Sep 29;335(6189):395–396. doi: 10.1038/335395a0. [DOI] [PubMed] [Google Scholar]
- Hartley J. W., Fredrickson T. N., Yetter R. A., Makino M., Morse H. C., 3rd Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J Virol. 1989 Mar;63(3):1223–1231. doi: 10.1128/jvi.63.3.1223-1231.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ikeda H., Laigret F., Martin M. A., Repaske R. Characterization of a molecularly cloned retroviral sequence associated with Fv-4 resistance. J Virol. 1985 Sep;55(3):768–777. doi: 10.1128/jvi.55.3.768-777.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ikeda H., Odaka T. Expression of Fv-4r allele in hematopoietic cells from G mice resistant to Friend leukemia virus. Int J Cancer. 1979 Apr 15;23(4):514–518. doi: 10.1002/ijc.2910230412. [DOI] [PubMed] [Google Scholar]
- Ikeda H., Sugimura H. Fv-4 resistance gene: a truncated endogenous murine leukemia virus with ecotropic interference properties. J Virol. 1989 Dec;63(12):5405–5412. doi: 10.1128/jvi.63.12.5405-5412.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kozak C. A., Gromet N. J., Ikeda H., Buckler C. E. A unique sequence related to the ecotropic murine leukemia virus is associated with the Fv-4 resistance gene. Proc Natl Acad Sci U S A. 1984 Feb;81(3):834–837. doi: 10.1073/pnas.81.3.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Odaka T., Ikeda H., Yoshikura H., Moriwaki K., Suzuki S. Fv-4: gene controlling resistance to NB-tropic Friend murine leukemia virus. Distribution in wild mice, introduction into genetic background of BALB/c mice, and mapping of chromosomes. J Natl Cancer Inst. 1981 Nov;67(5):1123–1127. [PubMed] [Google Scholar]
- Suzuki S. FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus. Jpn J Exp Med. 1975 Dec;45(6):473–478. [PubMed] [Google Scholar]
- Yoshikura H., Naito Y., Moriwaki K. Unstable resistance of G mouse fibroblasts to ecotropic murine leukemia virus infection. J Virol. 1979 Mar;29(3):1078–1086. doi: 10.1128/jvi.29.3.1078-1086.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoshikura H., Odaka T. Resistance of G mice to murine leukemia virus infection: apparent disparity in in vivo and in vitro resistances. J Natl Cancer Inst. 1978 Aug;61(2):461–463. [PubMed] [Google Scholar]
- Yoshikura H., Odaka T. Surface antigen expressed in hematopoietic cells derived from Fv-4r mouse strains. J Natl Cancer Inst. 1982 Jun;68(6):1005–1009. [PubMed] [Google Scholar]