Abstract
To evaluate the effectiveness of measles vaccine in reduced dosage, Schwarz live, further attenuated measles virus vaccine was given in various doses by jet injector to 967 seronegative children aged 7-30 months in rural villages in the Northwest State of Nigeria. For children over 12 months of age, reducing vaccine virus dosage by 40%, 60%, or 80% led to progressive and statistically significant reductions in the seroconversion rates from 89% in children receiving the full dose to a minimum value of 46%. Reducing the volume of the inoculum below the standard of 0.5 ml resulted in a further reduction of seroconversion rates at each antigen dose level. Seroconversion rates in all dosage groups were lower for children below 12 months of age. These data suggest that dose reduction would not be a satisfactory economy measure in measles vaccination campaigns.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Foege W. H., Eddins D. L. Mass vaccination programs in developing countries. Prog Med Virol. 1973;15:205–243. [PubMed] [Google Scholar]
- Grigsby M. E., Adetosoye J. I. Measles epidemiology and control in Western Nigeria. J Natl Med Assoc. 1973 Sep;65(5):378–385. [PMC free article] [PubMed] [Google Scholar]
- Guinee V. F., Henderson D. A., Casey H. L., Wingo S. T., Ruthig D. W., Cockburn T. A., Vinson T. O., Calafiore D. C., Winkelstein W., Jr, Karzon D. T. Cooperative measles vaccine field trial. I. Clinical efficacy. Pediatrics. 1966 Apr;37(4):649–665. [PubMed] [Google Scholar]
- Hayden R. J. Reduced dosage measles vaccination trial in Nairobi. East Afr Med J. 1972 Mar;49(3):213–218. [PubMed] [Google Scholar]
- Hendrickse R. G., Montefiore D. Measles vaccination with reduced dosage. Br Med J. 1968 Oct 5;4(5622):28–30. doi: 10.1136/bmj.4.5622.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rey M., Baylet R., Cantrelle P., Diop I., Dauchy S. La vaccination contre la rougeole par vaccins vivants. Deux expériences en Afrique tropicale (Sénégal) Presse Med. 1965 Nov 13;73(48):2729–2734. [PubMed] [Google Scholar]