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. 1975;52(4-6):409–419.

Morphology and morphogenesis of arenaviruses*

Frederick A Murphy, Sylvia G Whitfield
PMCID: PMC2366645  PMID: 182396

Abstract

Arenaviruses have unique structural characteristics; they are pleomorphic, have a mean diameter of 110-130 nm, and consist of a membranous envelope with surface projections surrounding an interior containing ribosomes and filaments. Virus particles bud from plasma membranes of infected cells and in many cases large intracytoplasmic inclusion bodies are formed. These characteristics allow generic identification, but not differentiation of individual viruses. Ultrastructural identification of virus particles and pathological processes in infected tissues of man and experimental animals is important in understanding the nature of arenaviral pathogenesis Such identification also contributes to our understanding of the mechanisms of viral shedding and transmission in reservoir host species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abelson H. T., Smith G. H., Hoffman H. A., Rowe W. P. Use of enzyme-labeled antibody for electron microscope localization of lymphocytic choriomeningitis virus antigens in infected cell cultures. J Natl Cancer Inst. 1969 Mar;42(3):497–515. [PubMed] [Google Scholar]
  2. Buckley S. M., Casals J. Lassa fever, a new virus disease of man from West Africa. 3. Isolation and characterization of the virus. Am J Trop Med Hyg. 1970 Jul;19(4):680–691. doi: 10.4269/ajtmh.1970.19.680. [DOI] [PubMed] [Google Scholar]
  3. Dalton A. J., Rowe W. P., Smith G. H., Wilsnack R. E., Pugh W. E. Morphological and cytochemical studies on lymphocytic choriomeningitis virus. J Virol. 1968 Dec;2(12):1465–1478. doi: 10.1128/jvi.2.12.1465-1478.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lascano E. F., Berría M. I. Ultrastructure of Junín virus in mouse whole brain and mouse brain tissue cultures. J Virol. 1974 Oct;14(4):965–974. doi: 10.1128/jvi.14.4.965-974.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Murphy F. A. Arenavirus taxonomy: a review. Bull World Health Organ. 1975;52(4-6):389–391. [PMC free article] [PubMed] [Google Scholar]
  6. Murphy F. A., Webb P. A., Johnson K. M., Whitfield S. G., Chappell W. A. Arenoviruses in Vero cells: ultrastructural studies. J Virol. 1970 Oct;6(4):507–518. doi: 10.1128/jvi.6.4.507-518.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murphy F. A., Webb P. A., Johnson K. M., Whitfield S. G. Morphological comparison of Machupo with lymphocytic choriomeningitis virus: basis for a new taxonomic group. J Virol. 1969 Oct;4(4):535–541. doi: 10.1128/jvi.4.4.535-541.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rowe W. P., Murphy F. A., Bergold G. H., Casals J., Hotchin J., Johnson K. M., Lehmann-Grube F., Mims C. A., Traub E., Webb P. A. Arenoviruses: proposed name for a newly defined virus group. J Virol. 1970 May;5(5):651–652. doi: 10.1128/jvi.5.5.651-652.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Walker D. H., Murphy F. A., Whitfield S. G., Bauer S. P. Lymphocytic choriomeningitis: ultrastructural pathology. Exp Mol Pathol. 1975 Oct;23(2):245–265. doi: 10.1016/0014-4800(75)90022-2. [DOI] [PubMed] [Google Scholar]
  10. Winn W. C., Jr, Walker D. H. The pathology of human Lassa fever. Bull World Health Organ. 1975;52(4-6):535–545. [PMC free article] [PubMed] [Google Scholar]

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