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. 1977;55(6):663–668.

Enterotoxin antibodies in relation to diarrhoea in Swedish soldiers in Cyprus

A-M Svennerholm, E Bäck, J Holmgren
PMCID: PMC2366719  PMID: 340076

Abstract

The development of antibodies to Escherichia coli heat-labile enterotoxin (LT) and its relationship to diarrhoea was studied in two Swedish battalions (one in the winter, WB, and one in the summer, SB) of the United Nations Peace-keeping Force in Cyprus. Whereas only 6-15% of the soldiers had detectable levels of anti-LT antibodies in their sera before leaving Sweden, as many as 69% of the SB and 43% of the WB soldiers who developed diarrhoea in Cyprus acquired significant titres of enterotoxin antibodies in their sera (acute phase serum). During the summer, many soldiers without diarrhoea also obtained anti-LT antibodies, whereas no such response was observed in healthy soldiers during the winter. Civilian Turkish Cypriots had positive sera in high frequency (60-66%) during both study periods. Parallel titration of positive sera against E. coli LT and cholera toxin indicated that the enterotoxin-neutralizing antibodies registered were induced by bacteria producing enterotoxin identical or closely related to LT.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Holmgren J., Söderlind O., Wadström T. Cross-reactivity between heat labile enterotoxins of Vibrio cholerae and Escherichia coli in neutralization tests in rabbit ileum and skin. Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Dec;81(6):757–762. doi: 10.1111/j.1699-0463.1973.tb02272.x. [DOI] [PubMed] [Google Scholar]
  2. Merson M. H., Morris G. K., Sack D. A., Wells J. G., Feeley J. C., Sack R. B., Creech W. B., Kapikian A. Z., Gangarosa E. J. Travelers' diarrhea in Mexico. A prospective study of physicians and family members attending a congress. N Engl J Med. 1976 Jun 10;294(24):1299–1305. doi: 10.1056/NEJM197606102942401. [DOI] [PubMed] [Google Scholar]
  3. Ryder R. W., Sack D. A., Kapikian A. Z., McLaughlin J. C., Chakraborty J., Mizanur Rahman A. S., Merson M. H., Wells J. G. Enterotoxigenic Escherichia coli and Reovirus-like agent in rural Bangladesh. Lancet. 1976 Mar 27;1(7961):659–663. doi: 10.1016/s0140-6736(76)92776-8. [DOI] [PubMed] [Google Scholar]
  4. Sack D. A., Sack R. B. Test for enterotoxigenic Escherichia coli using Y-1 adrenal cells in miniculture. Infect Immun. 1975 Feb;11(2):334–336. doi: 10.1128/iai.11.2.334-336.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Sack R. B. Human diarrheal disease caused by enterotoxigenic Escherichia coli. Annu Rev Microbiol. 1975;29:333–353. doi: 10.1146/annurev.mi.29.100175.002001. [DOI] [PubMed] [Google Scholar]
  6. Sack R. B., Jacobs B., Mitra R. Antitoxin responses to infections with enterotoxigenic Escherichia coli. J Infect Dis. 1974 Mar;129(3):330–335. doi: 10.1093/infdis/129.3.330. [DOI] [PubMed] [Google Scholar]

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