Abstract
Routine procedures for growing exoerythrocytic stages of avian malaria parasites in continuous culture have been available for many years. This system, adapted for the cultivation of mammalian forms, would have certain advantages in vaccine production, the great advantage being the potential for self-replication by both the host cell and the parasite. Many obstacles must be overcome, however, before efforts in this direction can be successful. The recent demonstration that merozoites of the exoerythrocytic cycle are immunogenic supports the view that efforts should be made to develop a mammalian culture system based on the exoerythrocytic stage.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Holbrook T. W., Spitalny G. L., Palczuk N. C. Stimulation of resistance in mice to sporozoite-induced Plasmodium berghei malaria by injections of avian exoerythrocytic forms. J Parasitol. 1976 Oct;62(5):670–675. [PubMed] [Google Scholar]
- Huff C. G., Coulston F., Cantrell W. MALARIAL CRYPTOZOITES. Science. 1943 Mar 26;97(2517):286–286. doi: 10.1126/science.97.2517.286. [DOI] [PubMed] [Google Scholar]
- Huff C. G. Exoerythrocytic stages of avian and reptilian malarial parasites. Exp Parasitol. 1969 Jun;24(3):383–421. doi: 10.1016/0014-4894(69)90176-3. [DOI] [PubMed] [Google Scholar]
- McGHEE R. B. The ability of the avian malaria parasite, Plasmodium lophurae, to infect erythrocytes of distantly related species of animals. Am J Hyg. 1950 Jul;52(1):42–47. doi: 10.1093/oxfordjournals.aje.a119407. [DOI] [PubMed] [Google Scholar]
- Nussenzweig R. S. Increased nonspecific resstance to malaria produced by administration of killed Corynebacterium parvum. Exp Parasitol. 1967 Oct;21(2):224–231. doi: 10.1016/0014-4894(67)90084-7. [DOI] [PubMed] [Google Scholar]
- PIPKIN A. C., JENSEN D. V. Avian embryos and tissue culture in the study of parasitic protozoa. I. Malarial parasites. Exp Parasitol. 1958 Sep;7(5):491–530. doi: 10.1016/0014-4894(58)90043-2. [DOI] [PubMed] [Google Scholar]