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. 1994;3(1):27–31. doi: 10.1155/S0962935194000050

Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes

J M Liebler 3,✉, S L Kunkel 1, R M Allen 1, M D Burdick 1, R M Strieter 2
PMCID: PMC2367013  PMID: 18472920

Abstract

Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. In contrast, stimulation with IFN-γ resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-γ and IL-1β or TNF-α resulted in no further increase in MCP-1 production. It is concluded that IFN-γ, primarily a product of TH1 T lymphocytes, stimulates the expression of MCP-1 by monocytes.

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Selected References

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