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. 1994;3(3):219–222. doi: 10.1155/S0962935194000311

Cytokine Production by Human Colonic Intraepithelial Lymphocytes in Controls and Ulcerative Colitis

P Hoang 1, H R Dalton 2, H J de Silv 2, D P Jewell 2,✉
PMCID: PMC2367034  PMID: 18472946

Abstract

Using an ELISA technique, concentrations of γ-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA). IntraepitheHal lymphocytes produced low concentrations of γ-interferon and interleukin-2 when stimulated with PHA, but significantly more than when unstimulated (p < 0.05). There was no difference in production of these cytokines by IEL from control or inflammatory bowel disease.

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Selected References

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  1. Braquet P., Hosford D., Braquet M., Bourgain R., Bussolino F. Role of cytokines and platelet-activating factor in microvascular immune injury. Int Arch Allergy Appl Immunol. 1989;88(1-2):88–100. doi: 10.1159/000234755. [DOI] [PubMed] [Google Scholar]
  2. Braquet P., Paubert-Braquet M., Bourgain R. H., Bussolino F., Hosford D. PAF/cytokine auto-generated feedback networks in microvascular immune injury: consequences in shock, ischemia and graft rejection. J Lipid Mediat. 1989 Mar-Apr;1(2):75–112. [PubMed] [Google Scholar]
  3. Curtis M. J., Macleod B. A., Walker M. J. Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat. J Mol Cell Cardiol. 1987 Apr;19(4):399–419. doi: 10.1016/s0022-2828(87)80585-0. [DOI] [PubMed] [Google Scholar]
  4. Hirai M., Okamura N., Terano Y., Tsujimoto M., Nakazato H. Production and characterization of monoclonal antibodies to human tumor necrosis factor. J Immunol Methods. 1987 Jan 26;96(1):57–62. doi: 10.1016/0022-1759(87)90367-x. [DOI] [PubMed] [Google Scholar]
  5. Janero D. R., Burghardt C. Production and release of platelet-activating factor by the injured heart-muscle cell (cardiomyocyte). Res Commun Chem Pathol Pharmacol. 1990 Feb;67(2):201–218. [PubMed] [Google Scholar]
  6. Joseph R., Welch K. M. Granulocytes, platelet-activating factor, and myocardial injury. Circulation. 1989 Jun;79(6):1401–1401. doi: 10.1161/01.cir.79.6.1401. [DOI] [PubMed] [Google Scholar]
  7. Koltai M., Hosford D., Guinot P., Esanu A., Braquet P. Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I). Drugs. 1991 Jul;42(1):9–29. doi: 10.2165/00003495-199142010-00002. [DOI] [PubMed] [Google Scholar]
  8. Ma X. L., Weyrich A. S., Krantz S., Lefer A. M. Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion. J Pharmacol Exp Ther. 1992 Mar;260(3):1229–1236. [PubMed] [Google Scholar]
  9. Maury C. P., Teppo A. M. Circulating tumour necrosis factor-alpha (cachectin) in myocardial infarction. J Intern Med. 1989 May;225(5):333–336. doi: 10.1111/j.1365-2796.1989.tb00090.x. [DOI] [PubMed] [Google Scholar]
  10. Montrucchio G., Alloatti G., Mariano F., de Paulis R., Comino A., Emanuelli G., Camussi G. Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart. Am J Pathol. 1990 Jul;137(1):71–83. [PMC free article] [PubMed] [Google Scholar]
  11. Sirois M. G., Plante G. E., Braquet P., Sirois P. Tumor necrosis factor primes the effects of platelet-activating factor on rat vascular permeability. J Lipid Mediat. 1990;2 (Suppl):S109–S117. [PubMed] [Google Scholar]
  12. Yue T. L., Rabinovici R., Farhat M., Feuerstein G. Inhibitory effect of new PAF antagonists on PAF-induced rabbit platelet aggregation in vitro and ex vivo. J Lipid Mediat. 1991 Jan-Feb;3(1):13–26. [PubMed] [Google Scholar]

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