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. 1994;3(3):177–180. doi: 10.1155/S0962935194000232

The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain

K G Go 1,✉, J G Ter Haar 2, L de Ley 2, F Zuiderveen 1, L Parente 4, E Solito 4, W M Molenaar 3
PMCID: PMC2367041  PMID: 18472938

Abstract

Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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