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. 1994 Jun;68(6):3453–3458. doi: 10.1128/jvi.68.6.3453-3458.1994

VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells.

S A Huber 1
PMCID: PMC236847  PMID: 7514674

Abstract

Murine VCAM-1 has been identified as a receptor for the D variant of encephalomyocarditis (EMC-D) virus on vascular endothelial cells from the heart. Monoclonal antibodies to VCAM-1 inhibited infection and lysis of endothelial cells with EMC-D virus. CHO cells transfected with the VCAM-1 gene were susceptible to EMC-D virus lysis, while control CHO cells transfected with the ELAM-1 gene were resistant. Similarly, 35S-labeled EMC-D virus bound to CHO-VCAM cells, and binding was inhibited with anti-VCAM-1 antibodies. Little or no radiolabeled virus bound to CHO-ELAM-1 cells.

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Selected References

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