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. 1994 Jun;68(6):4072–4074. doi: 10.1128/jvi.68.6.4072-4074.1994

Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus.

C M Posavad 1, J J Newton 1, K L Rosenthal 1
PMCID: PMC236920  PMID: 8189546

Abstract

The effect of herpes simplex virus type 1 (HSV-1) infection on human cytotoxic T-lymphocyte (CTL) lytic function was assessed. All HSV-infected CTL populations tested were significantly inhibited in lysing target cells. The inhibition of CTL lytic function by infection with HSV-1 was independent of T-cell receptor-mediated antigen recognition and did not involve virus-induced shutoff of host protein synthesis, the expression of the HSV-1 transactivation protein, ICP4, or replicating virus. Understanding the functional impairment of CTL following infection with HSV may have important implications for HSV-induced immunosuppression and the mechanism of HSV persistence in immunocompetent hosts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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