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. 1994 Jun;68(6):4104–4106. doi: 10.1128/jvi.68.6.4104-4106.1994

Cell-binding domain of adenovirus serotype 2 fiber.

N Louis 1, P Fender 1, A Barge 1, P Kitts 1, J Chroboczek 1
PMCID: PMC236926  PMID: 8189552

Abstract

The adenovirus fiber appears as a long, thin projection terminated by a knob (head). The fiber consists of a trimeric protein whose head domain is thought to interact with cell receptors. The head part (amino acids 388 to 582) of adenovirus type 2 fiber was produced in a baculovirus expression system. The purified protein was shown to cross-link into trimers. It was very resistant to proteolytic attack and seemed to attain a high degree of compactness. The head domain efficiently inhibited attachment of adenovirus to receptors on the surface of HeLa cells, thereby confirming the hypothesis that the head domain interacts with viral receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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