Skip to main content
NCBI home page
Canadian Family Physician logoLink to Canadian Family Physician
. 1971 Jul;17(7):34–36.

Alcoholic Liver Disease

Paul Devenyi
PMCID: PMC2370004  PMID: 20468662

Abstract

Alcoholic liver disease consists of well defined entities. Fatty liver is the commonest hepatic abnormality in alcoholics and in most cases it is reversible. Possibly a sustained fatty liver occasionally may induce fibrosis. Alcoholic hepatitis or subclinical necrosis may also proceed to hepatic fibrosis. The latter can regress if no further injury occurs or it may develop into frank cirrhosis in case of continuing liver injury. A general model of alcoholic liver disease is presented.

Full text

PDF
34

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILLINGTON B. P. A note on the distribution of ABO blood groups in bronchiectasis and portal cirrhosis. Australas Ann Med. 1956 Feb;5(1):20–22. doi: 10.1111/imj.1956.5.1.20. [DOI] [PubMed] [Google Scholar]
  2. CRUZ-COKE R. COLOUR-BLINDNESS AND CIRRHOSIS OF THE LIVER. Lancet. 1965 May 29;1(7396):1131–1133. doi: 10.1016/s0140-6736(65)91956-2. [DOI] [PubMed] [Google Scholar]
  3. Devenyi P., Rutherdale J., Sereny G., Olin J. S. Clinical diagnosis of alcoholic fatty liver. Am J Gastroenterol. 1970 Dec;54(6):597–602. [PubMed] [Google Scholar]
  4. Fialkow P. J., Thuline H. C., Fenster F. Lack of association between cirrhosis and the common types of color blindness. N Engl J Med. 1966 Sep 15;275(11):584–587. doi: 10.1056/NEJM196609152751104. [DOI] [PubMed] [Google Scholar]
  5. GREEN J., MISTILIS S., SCHIFF L. Acute alcoholic hepatitis. A clinical study of fifty cases. Arch Intern Med. 1963 Jul;112:67–78. doi: 10.1001/archinte.1963.03860010113013. [DOI] [PubMed] [Google Scholar]
  6. HORNING M. G., WILLIAMS E. A., MALING H. M., BRODIE B. B. Depot fat as source of increased liver triglycerides after ethanol. Biochem Biophys Res Commun. 1960 Dec;3:635–640. doi: 10.1016/0006-291x(60)90077-2. [DOI] [PubMed] [Google Scholar]
  7. LOMBARDI B., RECKNAGEL R. O. Interference with secretion of triglycerides by the liver as a common factor in toxic liver injury with some observations on choline deficiency fatty liver. Am J Pathol. 1962 May;40:571–586. [PMC free article] [PubMed] [Google Scholar]
  8. Lelbach W. K. Liver cell necrosis in rats after prolonged ethanol ingestion under the influence of an alcohol-dehydrogenase inhibitor. Experientia. 1969 Aug 15;25(8):816–818. doi: 10.1007/BF01897894. [DOI] [PubMed] [Google Scholar]
  9. Lieber C. S. Metabolic effects produced by alcohol in the liver and other tissues. Adv Intern Med. 1968;14:151–199. [PubMed] [Google Scholar]
  10. Lieber C. S., Spritz N. Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest. 1966 Sep;45(9):1400–1411. doi: 10.1172/JCI105448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MALLOV S. Effect of adrenalectomy on ethanol and fat metabolism in the rat. Am J Physiol. 1957 Jun;189(3):428–432. doi: 10.1152/ajplegacy.1957.189.3.428. [DOI] [PubMed] [Google Scholar]
  12. POPPER H., RUBIN E., KRUS S., SCHAFFNER F. Postnecrotic cirrhosis in alcoholics. Gastroenterology. 1960 Dec;39:669–689. [PubMed] [Google Scholar]
  13. Ravel R. Serum protein electrophoresis in cirrhosis. Am J Gastroenterol. 1969 Dec;52(6):509–514. [PubMed] [Google Scholar]

Articles from Canadian Family Physician are provided here courtesy of College of Family Physicians of Canada

RESOURCES