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. 1994 Oct;68(10):6332–6339. doi: 10.1128/jvi.68.10.6332-6339.1994

Involvement of human leukocyte antigen class I molecules in human immunodeficiency virus infection of CD4-positive cells.

M Benkirane 1, D Blanc-Zouaoui 1, M Hirn 1, C Devaux 1
PMCID: PMC237054  PMID: 7916059

Abstract

We have studied the putative roles of human immunodeficiency virus (HIV)-associated and cell surface-expressed major histocompatibility complex class I (MHC-I) molecules in the course of the HIV life cycle by the combined use of MHC-I molecule-positive and MHC-I molecule-negative virus particles and MHC-I molecule-positive and MHC-I molecule-negative CD4+ human cells. We found (i) that several anti-MHC-I monoclonal antibodies neutralize cell infection by direct interaction with HIV-associated MHC-I antigens, (ii) that these HIV-associated MHC-I antigens are however dispensable for cell infection, and (iii) that the cell surface-expressed MHC-I molecules are unnecessary for productive infection of CD4+ human cells. These results clarify further the functions of MHC-I molecules during the HIV life cycle.

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Selected References

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