Abstract
Our understanding of the basic pathogenetic mechanism of human allergic diseases was made possible by the discovery of IgE and the identification of this immunoglobulin as the key molecule in the mediation of human allergic reactions. The modern immunological principles in connection with the immediate hypersensitivity reaction can be applied to the management of allergic patients in terms of rational approaches in the areas of diagnosis and treatment.
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Selected References
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- Davis D. J. NIAID initiatives in allergy research. J Allergy Clin Immunol. 1972 Jun;49(6):323–328. doi: 10.1016/0091-6749(72)90130-3. [DOI] [PubMed] [Google Scholar]
- Ishizaka K., Ishizaka T. Mechanisms of reaginic hypersensitivity: a review. Clin Allergy. 1971 Mar;1(1):9–24. doi: 10.1111/j.1365-2222.1971.tb02444.x. [DOI] [PubMed] [Google Scholar]
- Johnstone D. E., Dutton A. The value of hyposensitization therapy for bronchial asthma in children--a 14-year study. Pediatrics. 1968 Nov;42(5):793–802. [PubMed] [Google Scholar]
- Levine B. B. Skin rashes with penicillin therapy: current management. N Engl J Med. 1972 Jan 6;286(1):42–43. doi: 10.1056/NEJM197201062860112. [DOI] [PubMed] [Google Scholar]
- Melam H., Pruzansky J., Patterson R., Singer S. Clinical and immunologic studies of ragweed immunotherapy. J Allergy. 1971 May;47(5):262–272. doi: 10.1016/s0091-6749(71)80004-0. [DOI] [PubMed] [Google Scholar]
- Reisman R. E. Asthma induced by adrenergic aerosols. J Allergy. 1970 Sep;46(3):162–177. doi: 10.1016/0021-8707(70)90095-x. [DOI] [PubMed] [Google Scholar]
