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. 1994 Nov;68(11):6918–6923. doi: 10.1128/jvi.68.11.6918-6923.1994

Characterization of a Borna disease virus glycoprotein, gp18.

S Kliche 1, T Briese 1, A H Henschen 1, L Stitz 1, W I Lipkin 1
PMCID: PMC237127  PMID: 7933072

Abstract

Borna disease virus is a nonsegmented negative-strand RNA virus that causes neurologic disease in a wide variety of animal hosts. Here we describe identification and characterization of the first glycoprotein in this viral system. The 18-kDa glycoprotein, gp18, has been purified from infected rat brain. Isolation and microsequencing of this protein allowed identification of a 16.2-kDa open reading frame in the viral antigenome. Lectin binding and endoglycosidase sensitivity assays indicate that gp18 is an unusual N-linked glycoprotein.

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Selected References

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