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. 1994 Nov;68(11):7534–7536. doi: 10.1128/jvi.68.11.7534-7536.1994

Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection.

D McKenzie 1, J Kaczkowski 1, R Marsh 1, J Aiken 1
PMCID: PMC237196  PMID: 7933137

Abstract

Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrP-res) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrP-res levels and titers were similar in treated and untreated animals. This suggests that although PrP-res accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease.

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Selected References

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