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. 1994 Dec;68(12):8331–8338. doi: 10.1128/jvi.68.12.8331-8338.1994

Cytotoxic activity against maedi-visna virus-infected macrophages.

W C Lee 1, I McConnell 1, B A Blacklaws 1
PMCID: PMC237302  PMID: 7966626

Abstract

The cell type predominantly infected by maedi-visna virus (MVV) is the macrophage, and we have looked at the ability of MVV-infected macrophages to interact with cytotoxic T lymphocytes (CTL), important effector cells against virus infections. MVV-specific CTL precursors were detected, after in vitro culture with MVV antigen and recombinant human interleukin-2, in peripheral blood lymphocytes of all MVV-infected sheep. MVV-infected monocyte-derived macrophages and alveolar macrophages were able to stimulate CTL activity in vitro and were targets for these activated CTL. The major effector cell population using MVV-infected macrophage targets was CD8+ lymphocytes, although another population, lymphokine-activated killer cells, may also have been involved. There was no direct cytotoxic activity found in alveolar lymphocytes from MVV-infected sheep without lung lesions.

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Selected References

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