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. 1997 Mar;1(1):55–58. doi: 10.1080/13577149778489

Simultaneous Epstein Barr Virus and Cytomegalovirus Infection Accompanied by Leiomyomatous Change in a Well-Differentiated Liposarcoma in a Patient With Long-Term Corticosteroid Treatment

Paul R A Sars 1, Willemina M Molenaar 2,3,✉, Jan Koudstaal 2, Harald J Hoekstra 1
PMCID: PMC2373577  PMID: 18521201

Abstract

Patient. A 59-year-old woman presented with a large tumour of the abdominal wall. She had been taking corticosteroids for severe chronic obstructive pulmonary disease for 15 years. On CT scan the tumour had the characteristics of lipomatous tissue with a dense core.

Results. Histology showed a well-differentiated liposarcoma with a core of benign fibroleiomyomatous differentiation. Within the core, a third component was observed, characterized by more pleomorphism and the presence of an inflammatory infiltrate. In this component, immunoperoxidase stains and in situ hybridization demonstrated cytomegalovirus (CMV) and Epstein Barr virus (EBV) infection in large and small cells, respectively.

Discussion. Long-term corticosteroid use for pulmonary disease may extend the list of immunosuppressed states associated with the development of leiomyomatous tumours with EBV infection, previously described in AIDS patients and liver transplant recipients. The role of CMV is uncertain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dahan H., Bèges C., Weiss L., Abitbol M., Ledreff O., Teman G., Belattar K., Rymer R. Leiomyoma of the adrenal gland in a patient with AIDS. Abdom Imaging. 1994 May-Jun;19(3):259–261. doi: 10.1007/BF00203522. [DOI] [PubMed] [Google Scholar]
  2. Evans H. L., Khurana K. K., Kemp B. L., Ayala A. G. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994 Nov;18(11):1150–1157. doi: 10.1097/00000478-199411000-00009. [DOI] [PubMed] [Google Scholar]
  3. Evans H. L. Smooth muscle in atypical lipomatous tumors. A report of three cases. Am J Surg Pathol. 1990 Aug;14(8):714–718. doi: 10.1097/00000478-199008000-00002. [DOI] [PubMed] [Google Scholar]
  4. Hardell L., Eriksson M. The association between soft tissue sarcomas and exposure to phenoxyacetic acids. A new case-referent study. Cancer. 1988 Aug 1;62(3):652–656. doi: 10.1002/1097-0142(19880801)62:3<652::aid-cncr2820620334>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  5. Kang H., Enzinger F. M., Breslin P., Feil M., Lee Y., Shepard B., Enziger F. Soft tissue sarcoma and military service in Vietnam: a case-control study. J Natl Cancer Inst. 1987 Oct;79(4):693–699. [PubMed] [Google Scholar]
  6. Laskin W. B., Silverman T. A., Enzinger F. M. Postradiation soft tissue sarcomas. An analysis of 53 cases. Cancer. 1988 Dec 1;62(11):2330–2340. doi: 10.1002/1097-0142(19881201)62:11<2330::aid-cncr2820621113>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  7. McClain K. L., Leach C. T., Jenson H. B., Joshi V. V., Pollock B. H., Parmley R. T., DiCarlo F. J., Chadwick E. G., Murphy S. B. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. N Engl J Med. 1995 Jan 5;332(1):12–18. doi: 10.1056/NEJM199501053320103. [DOI] [PubMed] [Google Scholar]
  8. McCormick D., Mentzel T., Beham A., Fletcher C. D. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol. 1994 Dec;18(12):1213–1223. doi: 10.1097/00000478-199412000-00004. [DOI] [PubMed] [Google Scholar]
  9. Prévot S., Néris J., de Saint Maur P. P. Detection of Epstein Barr virus in an hepatic leiomyomatous neoplasm in an adult human immunodeficiency virus 1-infected patient. Virchows Arch. 1994;425(3):321–325. doi: 10.1007/BF00196156. [DOI] [PubMed] [Google Scholar]
  10. Rabkin C. S. Epidemiology of AIDS-related malignancies. Curr Opin Oncol. 1994 Sep;6(5):492–496. doi: 10.1097/00001622-199409000-00008. [DOI] [PubMed] [Google Scholar]
  11. Salzano R. P., Jr, Tomkiewicz Z., Africano W. A. Dedifferentiated liposarcoma with features of rhabdomyosarcoma. Conn Med. 1991 Apr;55(4):200–202. [PubMed] [Google Scholar]
  12. Suster S., Wong T. Y., Moran C. A. Sarcomas with combined features of liposarcoma and leiomyosarcoma. Study of two cases of an unusual soft-tissue tumor showing dual lineage differentiation. Am J Surg Pathol. 1993 Sep;17(9):905–911. doi: 10.1097/00000478-199309000-00006. [DOI] [PubMed] [Google Scholar]
  13. Tallini G., Erlandson R. A., Brennan M. F., Woodruff J. M. Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. Am J Surg Pathol. 1993 Jun;17(6):546–556. doi: 10.1097/00000478-199306000-00002. [DOI] [PubMed] [Google Scholar]
  14. Timmons C. F., Dawson D. B., Richards C. S., Andrews W. S., Katz J. A. Epstein-Barr virus-associated leiomyosarcomas in liver transplantation recipients. Origin from either donor or recipient tissue. Cancer. 1995 Oct 15;76(8):1481–1489. doi: 10.1002/1097-0142(19951015)76:8<1481::aid-cncr2820760828>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  15. Weiss S. W., Rao V. K. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of "dedifferentiation". Am J Surg Pathol. 1992 Nov;16(11):1051–1058. doi: 10.1097/00000478-199211000-00003. [DOI] [PubMed] [Google Scholar]

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