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. 1999 Nov;81(5):890–892. doi: 10.1038/sj.bjc.6690781

Body weight and risk of soft-tissue sarcoma

A Tavani 1, M Soler 1, C La Vecchia 1,2, E Negri 1, S Gallus 1, S Franceschi 3
PMCID: PMC2374286  PMID: 10555763

Abstract

The relation between body mass (BMI) and soft-tissue sarcoma (STS) risk was evaluated in a case–control study from Northern Italy based on 217 incident STS and 1297 hospital controls. The risk of STS rose with BMI, with multivariate odds ratios of 3.49 (95% confidence interval (CI) 1.06–11.55) among men and 3.26 (95% CI 1.27–8.35) among women with a BMI >30 kg m–2 compared to those with BMI ≤ 20 kg m–2. © 1999 Cancer Research Campaign

Keywords: body mass index, case–control studies, obesity, overweight, soft-tissue sarcoma

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Selected References

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  1. Benn R. T. Some mathematical properties of weight-for-height indices used as measures of adiposity. Br J Prev Soc Med. 1971 Feb;25(1):42–50. doi: 10.1136/jech.25.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bertazzi A., Pesatori A. C., Consonni D., Tironi A., Landi M. T., Zocchetti C. Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiology. 1993 Sep;4(5):398–406. doi: 10.1097/00001648-199309000-00004. [DOI] [PubMed] [Google Scholar]
  3. Daughaday W. H. The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors. Endocrinology. 1990 Jul;127(1):1–4. doi: 10.1210/endo-127-1-1. [DOI] [PubMed] [Google Scholar]
  4. Friedman J. M. The alphabet of weight control. Nature. 1997 Jan 9;385(6612):119–120. doi: 10.1038/385119a0. [DOI] [PubMed] [Google Scholar]
  5. Galuska D. A., Serdula M., Pamuk E., Siegel P. Z., Byers T. Trends in overweight among US adults from 1987 to 1993: a multistate telephone survey. Am J Public Health. 1996 Dec;86(12):1729–1735. doi: 10.2105/ajph.86.12.1729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hoar S. K., Blair A., Holmes F. F., Boysen C. D., Robel R. J., Hoover R., Fraumeni J. F., Jr Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA. 1986 Sep 5;256(9):1141–1147. [PubMed] [Google Scholar]
  7. Hoppin J. A., Tolbert P. E., Herrick R. F., Freedman D. S., Ragsdale B. D., Horvat K. R., Brann E. A. Occupational chlorophenol exposure and soft tissue sarcoma risk among men aged 30-60 years. Am J Epidemiol. 1998 Oct 1;148(7):693–703. doi: 10.1093/aje/148.7.693. [DOI] [PubMed] [Google Scholar]
  8. Kang H. K., Watanabe K. K., Breen J., Remmers J., Conomos M. G., Stanley J., Flicker M. Dioxins and dibenzofurans in adipose tissue of US Vietnam veterans and controls. Am J Public Health. 1991 Mar;81(3):344–349. doi: 10.2105/ajph.81.3.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kang H., Enzinger F. M., Breslin P., Feil M., Lee Y., Shepard B., Enziger F. Soft tissue sarcoma and military service in Vietnam: a case-control study. J Natl Cancer Inst. 1987 Oct;79(4):693–699. [PubMed] [Google Scholar]
  10. Kogevinas M., Becher H., Benn T., Bertazzi P. A., Boffetta P., Bueno-de-Mesquita H. B., Coggon D., Colin D., Flesch-Janys D., Fingerhut M. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am J Epidemiol. 1997 Jun 15;145(12):1061–1075. doi: 10.1093/oxfordjournals.aje.a009069. [DOI] [PubMed] [Google Scholar]
  11. La Vecchia C., Lucchini F., Negri E., Boyle P., Maisonneuve P., Levi F. Trends of cancer mortality in Europe, 1955-1989: II, Respiratory tract, bone, connective and soft tissue sarcomas, and skin. Eur J Cancer. 1992;28(2-3):514–599. doi: 10.1016/s0959-8049(05)80091-7. [DOI] [PubMed] [Google Scholar]
  12. Lew E. A., Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. doi: 10.1016/0021-9681(79)90119-x. [DOI] [PubMed] [Google Scholar]
  13. Manson J. E., Stampfer M. J., Hennekens C. H., Willett W. C. Body weight and longevity. A reassessment. JAMA. 1987 Jan 16;257(3):353–358. [PubMed] [Google Scholar]
  14. Mantzoros C. S., Tzonou A., Signorello L. B., Stampfer M., Trichopoulos D., Adami H. O. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer. 1997;76(9):1115–1118. doi: 10.1038/bjc.1997.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Millar W. J. Distribution of body weight and height: comparison of estimates based on self-reported and observed measures. J Epidemiol Community Health. 1986 Dec;40(4):319–323. doi: 10.1136/jech.40.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Negri E., Pagano R., Decarli A., La Vecchia C. Body weight and the prevalence of chronic diseases. J Epidemiol Community Health. 1988 Mar;42(1):24–29. doi: 10.1136/jech.42.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nieto-García F. J., Bush T. L., Keyl P. M. Body mass definitions of obesity: sensitivity and specificity using self-reported weight and height. Epidemiology. 1990 Mar;1(2):146–152. [PubMed] [Google Scholar]
  18. Orban J. E., Stanley J. S., Schwemberger J. G., Remmers J. C. Dioxins and dibenzofurans in adipose tissue of the general US population and selected subpopulations. Am J Public Health. 1994 Mar;84(3):439–445. doi: 10.2105/ajph.84.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pagano R., La Vecchia C., Decarli A., Negri E., Franceschi S. Trends in overweight and obesity among Italian adults, 1983 through 1994. Am J Public Health. 1997 Nov;87(11):1869–1870. doi: 10.2105/ajph.87.11.1869. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Palta M., Prineas R. J., Berman R., Hannan P. Comparison of self-reported and measured height and weight. Am J Epidemiol. 1982 Feb;115(2):223–230. doi: 10.1093/oxfordjournals.aje.a113294. [DOI] [PubMed] [Google Scholar]
  21. Patterson D. G., Jr, Hoffman R. E., Needham L. L., Roberts D. W., Bagby J. R., Pirkle J. L., Falk H., Sampson E. J., Houk V. N. 2,3,7,8-Tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report. JAMA. 1986 Nov 21;256(19):2683–2686. [PubMed] [Google Scholar]
  22. Petridou E., Dessypris N., Spanos E., Mantzoros C., Skalkidou A., Kalmanti M., Koliouskas D., Kosmidis H., Panagiotou J. P., Piperopoulou F. Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia. Int J Cancer. 1999 Feb 9;80(4):494–496. doi: 10.1002/(sici)1097-0215(19990209)80:4<494::aid-ijc2>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  23. Reif J., Pearce N., Kawachi I., Fraser J. Soft-tissue sarcoma, non-Hodgkin's lymphoma and other cancers in New Zealand forestry workers. Int J Cancer. 1989 Jan 15;43(1):49–54. doi: 10.1002/ijc.2910430112. [DOI] [PubMed] [Google Scholar]
  24. Ross J. A., Severson R. K., Davis S., Brooks J. J. Trends in the incidence of soft tissue sarcomas in the United States from 1973 through 1987. Cancer. 1993 Jul 15;72(2):486–490. doi: 10.1002/1097-0142(19930715)72:2<486::aid-cncr2820720226>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  25. Saracci R., Kogevinas M., Bertazzi P. A., Bueno de Mesquita B. H., Coggon D., Green L. M., Kauppinen T., L'Abbé K. A., Littorin M., Lynge E. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet. 1991 Oct 26;338(8774):1027–1032. doi: 10.1016/0140-6736(91)91898-5. [DOI] [PubMed] [Google Scholar]
  26. Serraino D., Franceschi S., Talamini R., Frustaci S., La Vecchia C. Non-occupational risk factors for adult soft-tissue sarcoma in northern Italy. Cancer Causes Control. 1991 May;2(3):157–164. doi: 10.1007/BF00056208. [DOI] [PubMed] [Google Scholar]
  27. Stewart A. L. The reliability and validity of self-reported weight and height. J Chronic Dis. 1982;35(4):295–309. doi: 10.1016/0021-9681(82)90085-6. [DOI] [PubMed] [Google Scholar]
  28. Tavani A., Pregnolato A., Negri E., Franceschi S., Serraino D., Carbone A., La Vecchia C. Diet and risk of lymphoid neoplasms and soft tissue sarcomas. Nutr Cancer. 1997;27(3):256–260. doi: 10.1080/01635589709514535. [DOI] [PubMed] [Google Scholar]
  29. Tritos N. A., Mantzoros C. S. Recombinant human growth hormone: old and novel uses. Am J Med. 1998 Jul;105(1):44–57. doi: 10.1016/s0002-9343(98)00135-1. [DOI] [PubMed] [Google Scholar]
  30. Woods J. S., Polissar L., Severson R. K., Heuser L. S., Kulander B. G. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. J Natl Cancer Inst. 1987 May;78(5):899–910. [PubMed] [Google Scholar]
  31. Zahm S. H., Blair A., Holmes F. F., Boysen C. D., Robel R. J., Fraumeni J. F., Jr A case-control study of soft-tissue sarcoma. Am J Epidemiol. 1989 Oct;130(4):665–674. doi: 10.1093/oxfordjournals.aje.a115388. [DOI] [PubMed] [Google Scholar]
  32. Zahm S. H., Fraumeni J. F., Jr The epidemiology of soft tissue sarcoma. Semin Oncol. 1997 Oct;24(5):504–514. [PubMed] [Google Scholar]

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