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. 2000 Apr 27;82(10):1646–1649. doi: 10.1054/bjoc.2000.1221

Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma

G Liu 1, P Ghadirian 2, D Vesprini 1, N Hamel 3, A-J Paradis 2, G Lal 4, S Gallinger 4, S A Narod 1, W D Foulkes 3
PMCID: PMC2374522  PMID: 10817498

Abstract

A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer. © 2000 Cancer Research Campaign

Keywords: pancreatic cancer, genetic susceptibility, cytochrome P450, glutathione S-transferase

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Selected References

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  1. Bartsch H., Malaveille C., Lowenfels A. B., Maisonneuve P., Hautefeuille A., Boyle P. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group. Eur J Cancer Prev. 1998 Jun;7(3):215–223. doi: 10.1097/00008469-199806000-00006. [DOI] [PubMed] [Google Scholar]
  2. Flanders T. Y., Foulkes W. D. Pancreatic adenocarcinoma: epidemiology and genetics. J Med Genet. 1996 Nov;33(11):889–898. doi: 10.1136/jmg.33.11.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Foulkes W. D., Brunet J. S., Sieh W., Black M. J., Shenouda G., Narod S. A. Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study. BMJ. 1996 Sep 21;313(7059):716–721. doi: 10.1136/bmj.313.7059.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hirvonen A. Genetic factors in individual responses to environmental exposures. J Occup Environ Med. 1995 Jan;37(1):37–43. doi: 10.1097/00043764-199501000-00006. [DOI] [PubMed] [Google Scholar]
  5. Howe G. R., Burch J. D. Nutrition and pancreatic cancer. Cancer Causes Control. 1996 Jan;7(1):69–82. doi: 10.1007/BF00115639. [DOI] [PubMed] [Google Scholar]
  6. Lee H. C., Yoon Y. B., Kim C. Y. Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer. Korean J Intern Med. 1997 Jun;12(2):128–136. doi: 10.3904/kjim.1997.12.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pemble S., Schroeder K. R., Spencer S. R., Meyer D. J., Hallier E., Bolt H. M., Ketterer B., Taylor J. B. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 1994 May 15;300(Pt 1):271–276. doi: 10.1042/bj3000271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Persson I., Johansson I., Ingelman-Sundberg M. In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem Biophys Res Commun. 1997 Feb 3;231(1):227–230. doi: 10.1006/bbrc.1997.6051. [DOI] [PubMed] [Google Scholar]
  9. Rebbeck T. R. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 1997 Sep;6(9):733–743. [PubMed] [Google Scholar]
  10. Rebbeck T. R., Rosvold E. A., Duggan D. J., Zhang J., Buetow K. H. Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer. Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):511–514. [PubMed] [Google Scholar]
  11. Xu X., Kelsey K. T., Wiencke J. K., Wain J. C., Christiani D. C. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):687–692. [PubMed] [Google Scholar]
  12. Zhang Z. Y., Fasco M. J., Huang L., Guengerich F. P., Kaminsky L. S. Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis. Cancer Res. 1996 Sep 1;56(17):3926–3933. [PubMed] [Google Scholar]
  13. Zhong S., Wyllie A. H., Barnes D., Wolf C. R., Spurr N. K. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993 Sep;14(9):1821–1824. doi: 10.1093/carcin/14.9.1821. [DOI] [PubMed] [Google Scholar]

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