Abstract
Mammographic parenchymal patterns are related to breast cancer risk and are also thought to be affected by diet. We designed a case–control study comprising 200 cases with high-risk (P2 and DY) mammographic parenchymal pattern and 200 controls with low-risk (N1 and P1) patterns in order to investigate the effect of food and nutrient intake on mammographic patterns. Mammograms were evaluated according to the Wolfe classification system. Dietary data were obtained from 7-day food diaries. Mean daily intake of nutrients was computed from standard UK food tables. The adjusted odds ratio (OR) of having a high-risk pattern in women in the highest tertile of total protein and carbohydrate intake was twice that of women in the lowest tertile (OR = 2.00; 95% confidence interval (CI) 1.06–3.77;P = 0.04 and OR = 1.93; 95% CI 1.03–3.59;P = 0.04 respectively). There was no excess risk for fat intake. In addition, there was no association between intake of vitamins and mammographic parenchymal patterns. Total meat intake was strongly and positively associated with high-risk patterns among post-menopausal women (OR = 2.50, 95% CI 1.09–5.69, P = 0.03). Our study suggests that certain macronutrients and foods such as protein, carbohydrate and meat intake influence the risk of breast cancer through their effects on breast tissue morphology, whereas fat and vitamins do not affect mammographic density. It seems that parenchymal pattern acts as an informative biomarker of the effect of some macronutrient and foodstuffs intake on breast cancer risk. © 2000 Cancer Research Campaign
Keywords: mammographic parenchymal patterns, diet, tertile
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- Armstrong B. K., Brown J. B., Clarke H. T., Crooke D. K., Hähnel R., Masarei J. R., Ratajczak T. Diet and reproductive hormones: a study of vegetarian and nonvegetarian postmenopausal women. J Natl Cancer Inst. 1981 Oct;67(4):761–767. [PubMed] [Google Scholar]
- Bingham S. A., Gill C., Welch A., Day K., Cassidy A., Khaw K. T., Sneyd M. J., Key T. J., Roe L., Day N. E. Comparison of dietary assessment methods in nutritional epidemiology: weighed records v. 24 h recalls, food-frequency questionnaires and estimated-diet records. Br J Nutr. 1994 Oct;72(4):619–643. doi: 10.1079/bjn19940064. [DOI] [PubMed] [Google Scholar]
- Boyd N. F., Cousins M., Beaton M., Fishell E., Wright B., Fish E., Kriukov V., Lockwood G., Tritchler D., Hanna W. Clinical trial of low-fat, high-carbohydrate diet in subjects with mammographic dysplasia: report of early outcomes. J Natl Cancer Inst. 1988 Oct 5;80(15):1244–1248. doi: 10.1093/jnci/80.15.1244. [DOI] [PubMed] [Google Scholar]
- Boyd N. F., Greenberg C., Lockwood G., Little L., Martin L., Byng J., Yaffe M., Tritchler D. Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst. 1997 Apr 2;89(7):488–496. doi: 10.1093/jnci/89.7.488. [DOI] [PubMed] [Google Scholar]
- Boyd N. F., Martin L. J., Noffel M., Lockwood G. A., Trichler D. L. A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer. 1993 Sep;68(3):627–636. doi: 10.1038/bjc.1993.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyd N. F., McGuire V., Fishell E., Kuriov V., Lockwood G., Tritchler D. Plasma lipids in premenopausal women with mammographic dysplasia. Br J Cancer. 1989 May;59(5):766–771. doi: 10.1038/bjc.1989.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brisson J., Verreault R., Morrison A. S., Tennina S., Meyer F. Diet, mammographic features of breast tissue, and breast cancer risk. Am J Epidemiol. 1989 Jul;130(1):14–24. doi: 10.1093/oxfordjournals.aje.a115305. [DOI] [PubMed] [Google Scholar]
- Clavel-Chapelon F., Niravong M., Joseph R. R. Diet and breast cancer: review of the epidemiologic literature. Cancer Detect Prev. 1997;21(5):426–440. [PubMed] [Google Scholar]
- Day N., Oakes S., Luben R., Khaw K. T., Bingham S., Welch A., Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 (Suppl 1):95–103. [PubMed] [Google Scholar]
- Goldin B. R., Adlercreutz H., Gorbach S. L., Warram J. H., Dwyer J. T., Swenson L., Woods M. N. Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. N Engl J Med. 1982 Dec 16;307(25):1542–1547. doi: 10.1056/NEJM198212163072502. [DOI] [PubMed] [Google Scholar]
- Hunter D. J., Spiegelman D., Adami H. O., Beeson L., van den Brandt P. A., Folsom A. R., Fraser G. E., Goldbohm R. A., Graham S., Howe G. R. Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. N Engl J Med. 1996 Feb 8;334(6):356–361. doi: 10.1056/NEJM199602083340603. [DOI] [PubMed] [Google Scholar]
- Knight J. A., Martin L. J., Greenberg C. V., Lockwood G. A., Byng J. W., Yaffe M. J., Tritchler D. L., Boyd N. F. Macronutrient intake and change in mammographic density at menopause: results from a randomized trial. Cancer Epidemiol Biomarkers Prev. 1999 Feb;8(2):123–128. [PubMed] [Google Scholar]
- Nordevang E., Azavedo E., Svane G., Nilsson B., Holm L. E. Dietary habits and mammographic patterns in patients with breast cancer. Breast Cancer Res Treat. 1993;26(3):207–215. doi: 10.1007/BF00665798. [DOI] [PubMed] [Google Scholar]
- Saftlas A. F., Szklo M. Mammographic parenchymal patterns and breast cancer risk. Epidemiol Rev. 1987;9:146–174. doi: 10.1093/oxfordjournals.epirev.a036300. [DOI] [PubMed] [Google Scholar]
- Sala E., Warren R., McCann J., Duffy S., Day N., Luben R. Mammographic parenchymal patterns and mode of detection: implications for the breast screening programme. J Med Screen. 1998;5(4):207–212. doi: 10.1136/jms.5.4.207. [DOI] [PubMed] [Google Scholar]
- Sala E., Warren R., McCann J., Duffy S., Luben R., Day N. High-risk mammographic parenchymal patterns and anthropometric measures: a case-control study. Br J Cancer. 1999 Dec;81(7):1257–1261. doi: 10.1038/sj.bjc.6690838. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Toniolo P., Riboli E., Shore R. E., Pasternack B. S. Consumption of meat, animal products, protein, and fat and risk of breast cancer: a prospective cohort study in New York. Epidemiology. 1994 Jul;5(4):391–397. doi: 10.1097/00001648-199407000-00003. [DOI] [PubMed] [Google Scholar]
- Vatten L. J., Solvoll K., Løken E. B. Frequency of meat and fish intake and risk of breast cancer in a prospective study of 14,500 Norwegian women. Int J Cancer. 1990 Jul 15;46(1):12–15. doi: 10.1002/ijc.2910460105. [DOI] [PubMed] [Google Scholar]
- Warner E., Lockwood G., Tritchler D., Boyd N. F. The risk of breast cancer associated with mammographic parenchymal patterns: a meta-analysis of the published literature to examine the effect of method of classification. Cancer Detect Prev. 1992;16(1):67–72. [PubMed] [Google Scholar]
- Willett W. C., Hunter D. J., Stampfer M. J., Colditz G., Manson J. E., Spiegelman D., Rosner B., Hennekens C. H., Speizer F. E. Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA. 1992 Oct 21;268(15):2037–2044. [PubMed] [Google Scholar]
- Wolfe J. N. Breast patterns as an index of risk for developing breast cancer. AJR Am J Roentgenol. 1976 Jun;126(6):1130–1137. doi: 10.2214/ajr.126.6.1130. [DOI] [PubMed] [Google Scholar]