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. 2000 Jul 3;83(3):360–365. doi: 10.1054/bjoc.2000.1261

Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption

J W Chiao 1, B S Moonga 1, Y M Yang 1, R Kancherla 1, A Mittelman 1, J R Wu-Wong 2, T Ahmed 1
PMCID: PMC2374574  PMID: 10917552

Abstract

The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-1 (ET-1) mRNA and its production. ET-1 is an ejaculate protein that also stimulates osteoblasts. Osteoclastic bone resorption was significantly blocked by the presence of androgen-independent prostate cancer cells in a dose-dependent manner as that of synthetic ET-1. The inhibition could be neutralized by specific ET-1 antibody, indicating the association of prostate cancer-derived ET-1 with inhibition of bone resorption. The combined ET-1 activity on osteoclasts and osteoblasts disrupts bone remodelling. ET-1 production is also elevated in the presence of prostate-specific antigen (PSA). ET-1 in turn enhances DNA synthesis of prostate cancer cells. Interactions among cancer cells, bone, ET-1 and PSA may be critical in cancer growth and lesions in bone. © 2000 Cancer Research Campaign

Keywords: prostate cancer, endothelin-1, bone lesions

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Selected References

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