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. 2000 Sep 4;83(7):964–968. doi: 10.1054/bjoc.2000.1370

Birthweight, childhood growth and risk of breast cancer in a British cohort

B L De Stavola 1, R Hardy 2, D Kuh 2, I dos Santos Silva 1, M Wadsworth 2, A J Swerdlow 1
PMCID: PMC2374673  PMID: 10970703

Abstract

We have examined the relationship between birthweight and risk of breast cancer, taking into account growth in childhood, using data on a total of 2221 women born in 1946 and followed up to 1997. Thirty-seven breast cancers occurred during follow-up. There was evidence of greater risk of breast cancer with greater birthweight (rate ratio = 1.76 (95% CI: 0.92, 3.35) for birthweight ≥ 3.5 kg vs birthweight < 3.5 kg), which was more marked at pre-menopausal ages (RR = 2.31, 95% CI: 0.93, 5.74). The relation with birthweight was not substantially confounded by any of the measured adult risk factors. A significant interaction was observed between the effects of birthweight and height at age 7 years. Relative to those born lighter than 3.5 kg, women who were heavy at birth (≥ 3.5 kg) and short or average at 7 years (< 1.22 m) had a 21% increase in breast cancer rates (RR = 1.21; 95% CI = 0.49–2.99), while women who were heavy at birth (≥ 3.5 kg) but tall at 7 years (≥ 1.22 m) had a four-fold increase (RR = 4.01; 95% CI = 1.82–8.83). These results suggest that the effect of birthweight on breast cancer risk may be modulated by childhood growth. © 2000 Cancer Research Campaign

Keywords: birthweight, childhood growth, breast cancer, cohort study

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Selected References

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  1. Braun M. M., Ahlbom A., Floderus B., Brinton L. A., Hoover R. N. Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control. 1995 Nov;6(6):519–524. doi: 10.1007/BF00054160. [DOI] [PubMed] [Google Scholar]
  2. Ekbom A., Hsieh C. C., Lipworth L., Adami H. Q., Trichopoulos D. Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997 Jan 1;89(1):71–76. doi: 10.1093/jnci/89.1.71. [DOI] [PubMed] [Google Scholar]
  3. Ekbom A., Trichopoulos D., Adami H. O., Hsieh C. C., Lan S. J. Evidence of prenatal influences on breast cancer risk. Lancet. 1992 Oct 24;340(8826):1015–1018. doi: 10.1016/0140-6736(92)93019-j. [DOI] [PubMed] [Google Scholar]
  4. Frisch R. E. Body fat, menarche, fitness and fertility. Hum Reprod. 1987 Aug;2(6):521–533. doi: 10.1093/oxfordjournals.humrep.a136582. [DOI] [PubMed] [Google Scholar]
  5. Gunnell D. J., Davey Smith G., Frankel S., Nanchahal K., Braddon F. E., Pemberton J., Peters T. J. Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. J Epidemiol Community Health. 1998 Mar;52(3):142–152. doi: 10.1136/jech.52.3.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hankinson S. E., Willett W. C., Colditz G. A., Hunter D. J., Michaud D. S., Deroo B., Rosner B., Speizer F. E., Pollak M. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998 May 9;351(9113):1393–1396. doi: 10.1016/S0140-6736(97)10384-1. [DOI] [PubMed] [Google Scholar]
  7. Holly J. Insulin-like growth factor-I and new opportunities for cancer prevention. Lancet. 1998 May 9;351(9113):1373–1375. doi: 10.1016/S0140-6736(05)79438-1. [DOI] [PubMed] [Google Scholar]
  8. Kappel B., Hansen K., Moller J., Faaborg-Andersen J. Human placental lactogen and dU-estrogen levels in normal twin pregnancies. Acta Genet Med Gemellol (Roma) 1985;34(1-2):59–65. doi: 10.1017/s000156600000492x. [DOI] [PubMed] [Google Scholar]
  9. Martin N. G., El Beaini J. L., Olsen M. E., Bhatnagar A. S., Macourt D. Gonadotropin levels in mothers who have had two sets of DZ twins. Acta Genet Med Gemellol (Roma) 1984;33(1):131–139. doi: 10.1017/s0001566000007613. [DOI] [PubMed] [Google Scholar]
  10. Michels K. B., Trichopoulos D., Robins J. M., Rosner B. A., Manson J. E., Hunter D. J., Colditz G. A., Hankinson S. E., Speizer F. E., Willett W. C. Birthweight as a risk factor for breast cancer. Lancet. 1996 Dec 7;348(9041):1542–1546. doi: 10.1016/S0140-6736(96)03102-9. [DOI] [PubMed] [Google Scholar]
  11. Nylander P. P. The factors that influence twinning rates. Acta Genet Med Gemellol (Roma) 1981;30(3):189–202. doi: 10.1017/s0001566000007650. [DOI] [PubMed] [Google Scholar]
  12. Petridou E., Panagiotopoulou K., Katsouyanni K., Spanos E., Trichopoulos D. Tobacco smoking, pregnancy estrogens, and birth weight. Epidemiology. 1990 May;1(3):247–250. doi: 10.1097/00001648-199005000-00011. [DOI] [PubMed] [Google Scholar]
  13. Sanderson M., Williams M. A., Malone K. E., Stanford J. L., Emanuel I., White E., Daling J. R. Perinatal factors and risk of breast cancer. Epidemiology. 1996 Jan;7(1):34–37. doi: 10.1097/00001648-199601000-00007. [DOI] [PubMed] [Google Scholar]
  14. Stark O., Atkins E., Wolff O. H., Douglas J. W. Longitudinal study of obesity in the National Survey of Health and Development. Br Med J (Clin Res Ed) 1981 Jul 4;283(6283):13–17. doi: 10.1136/bmj.283.6283.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stoll B. A., Vatten L. J., Kvinnsland S. Does early physical maturity influence breast cancer risk? Acta Oncol. 1994;33(2):171–176. doi: 10.3109/02841869409098400. [DOI] [PubMed] [Google Scholar]
  16. Swerdlow A. J., De Stavola B. L., Swanwick M. A., Maconochie N. E. Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology. Lancet. 1997 Dec 13;350(9093):1723–1728. doi: 10.1016/s0140-6736(97)05526-8. [DOI] [PubMed] [Google Scholar]
  17. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet. 1990 Apr 21;335(8695):939–940. doi: 10.1016/0140-6736(90)91000-z. [DOI] [PubMed] [Google Scholar]
  18. Wadsworth M. E., Kuh D. J. Childhood influences on adult health: a review of recent work from the British 1946 national birth cohort study, the MRC National Survey of Health and Development. Paediatr Perinat Epidemiol. 1997 Jan;11(1):2–20. doi: 10.1046/j.1365-3016.1997.d01-7.x. [DOI] [PubMed] [Google Scholar]
  19. Wadsworth M. E., Mann S. L., Rodgers B., Kuh D. J., Hilder W. S., Yusuf E. J. Loss and representativeness in a 43 year follow up of a national birth cohort. J Epidemiol Community Health. 1992 Jun;46(3):300–304. doi: 10.1136/jech.46.3.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. de Waard F., Trichopoulos D. A unifying concept of the aetiology of breast cancer. Int J Cancer. 1988 May 15;41(5):666–669. doi: 10.1002/ijc.2910410505. [DOI] [PubMed] [Google Scholar]

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