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. 2000 Sep 4;83(7):956–958. doi: 10.1054/bjoc.2000.1382

Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland

A Auvinen 1,2, T Hakulinen 3,4, F Groves 5
PMCID: PMC2374693  PMID: 10970701

Abstract

Incidence of childhood leukaemia was studied among subjects of a trial comparing administration of several doses of a conjugate vaccine against Haemophilus influenzae type b (Hib) starting at an early age (three months) with a single dose given at the age of two years. Among 114 000 subjects, a total of 77 cases of childhood leukaemia were detected. The incidence of childhood leukaemia was lower in the early vaccination arm (relative risk 0.72, 95% confidence interval 0.46–1.13) than late vaccination arm, but the difference did not reach statistical significance. Our results suggest that early immunization against Hib may reduce the incidence of childhood leukaemia, but confirmatory studies are needed. © 2000 Cancer Research Campaign

Keywords: leukaemia, child, vaccinations, Haemophilus influenzae type b, Haemophilus influenzae type b polysaccharide vaccine diphtheria toxoid conjugate, clinical trials

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Selected References

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  1. Dockerty J. D., Skegg D. C., Elwood J. M., Herbison G. P., Becroft D. M., Lewis M. E. Infections, vaccinations, and the risk of childhood leukaemia. Br J Cancer. 1999 Jul;80(9):1483–1489. doi: 10.1038/sj.bjc.6690548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eskola J., Käyhty H., Takala A. K., Peltola H., Rönnberg P. R., Kela E., Pekkanen E., McVerry P. H., Mäkelä P. H. A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. N Engl J Med. 1990 Nov 15;323(20):1381–1387. doi: 10.1056/NEJM199011153232004. [DOI] [PubMed] [Google Scholar]
  3. Greaves M. F. Aetiology of acute leukaemia. Lancet. 1997 Feb 1;349(9048):344–349. doi: 10.1016/s0140-6736(96)09412-3. [DOI] [PubMed] [Google Scholar]
  4. Greaves M. Molecular genetics, natural history and the demise of childhood leukaemia. Eur J Cancer. 1999 Feb;35(2):173–185. doi: 10.1016/s0959-8049(98)00433-x. [DOI] [PubMed] [Google Scholar]
  5. Groves F. D., Gridley G., Wacholder S., Shu X. O., Robison L. L., Neglia J. P., Linet M. S. Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA. Br J Cancer. 1999 Sep;81(1):175–178. doi: 10.1038/sj.bjc.6690668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hartley A. L., Birch J. M., McKinney P. A., Blair V., Teare M. D., Carrette J., Mann J. R., Stiller C. A., Draper G. J., Johnston H. E. The Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): past medical history in children with cancer. J Epidemiol Community Health. 1988 Sep;42(3):235–242. doi: 10.1136/jech.42.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. INNIS M. D. IMMUNISATION AND CHILDHOOD LEUKAEMIA. Lancet. 1965 Mar 13;1(7385):605–605. doi: 10.1016/s0140-6736(65)91188-8. [DOI] [PubMed] [Google Scholar]
  8. Kaatsch P., Kaletsch U., Krummenauer F., Meinert R., Miesner A., Haaf G., Michaelis J. Case control study on childhood leukemia in Lower Saxony, Germany. Basic considerations, methodology, and summary of results. Klin Padiatr. 1996 Jul-Aug;208(4):179–185. doi: 10.1055/s-2008-1046470. [DOI] [PubMed] [Google Scholar]
  9. Kinlen L. J. Infection and childhood leukemia. Cancer Causes Control. 1998 May;9(3):237–239. doi: 10.1023/a:1017149601195. [DOI] [PubMed] [Google Scholar]
  10. Kneale G. W., Stewart A. M., Wilson L. M. Immunizations against infectious diseases and childhood cancers. Cancer Immunol Immunother. 1986;21(2):129–132. doi: 10.1007/BF00199860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McKinney P. A., Cartwright R. A., Saiu J. M., Mann J. R., Stiller C. A., Draper G. J., Hartley A. L., Hopton P. A., Birch J. M., Waterhouse J. A. The inter-regional epidemiological study of childhood cancer (IRESCC): a case control study of aetiological factors in leukaemia and lymphoma. Arch Dis Child. 1987 Mar;62(3):279–287. doi: 10.1136/adc.62.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nishi M., Miyake H. A case-control study of non-T cell acute lymphoblastic leukaemia of children in Hokkaido, Japan. J Epidemiol Community Health. 1989 Dec;43(4):352–355. doi: 10.1136/jech.43.4.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Peltola H., Eskola J., Käyhty H., Takala A. K., Mäkelä P. H. Clinical comparison of the Haemophilus influenzae type B polysaccharide-diphtheria toxoid and the oligosaccharide-CRM197 protein vaccines in infancy. Arch Pediatr Adolesc Med. 1994 Jun;148(6):620–625. doi: 10.1001/archpedi.1994.02170060074015. [DOI] [PubMed] [Google Scholar]
  14. Peltola H., Kilpi T., Anttila M. Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines. Lancet. 1992 Sep 5;340(8819):592–594. doi: 10.1016/0140-6736(92)92117-x. [DOI] [PubMed] [Google Scholar]
  15. Salonen T. Prenatal and perinatal factors in childhood cancer. Ann Clin Res. 1976 Feb;8(1):27–42. [PubMed] [Google Scholar]
  16. Schneerson R., Barrera O., Sutton A., Robbins J. B. Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates. J Exp Med. 1980 Aug 1;152(2):361–376. doi: 10.1084/jem.152.2.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schüz J., Kaletsch U., Meinert R., Kaatsch P., Michaelis J. Association of childhood leukaemia with factors related to the immune system. Br J Cancer. 1999 May;80(3-4):585–590. doi: 10.1038/sj.bjc.6690395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Smith M. A., Chen T., Simon R. Age-specific incidence of acute lymphoblastic leukemia in U.S. children: in utero initiation model. J Natl Cancer Inst. 1997 Oct 15;89(20):1542–1544. doi: 10.1093/jnci/89.20.1542. [DOI] [PubMed] [Google Scholar]
  19. Stewart A. M., Hewitt D. Aetiology of childhood leukaemia. Lancet. 1965 Oct 16;2(7416):789–790. doi: 10.1016/s0140-6736(65)90835-4. [DOI] [PubMed] [Google Scholar]
  20. Takala A. K., Eskola J., Leinonen M., Käyhty H., Nissinen A., Pekkanen E., Mäkelä P. H. Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. J Infect Dis. 1991 Nov;164(5):982–986. doi: 10.1093/infdis/164.5.982. [DOI] [PubMed] [Google Scholar]
  21. Takala A. K., Peltola H., Eskola J. Disappearance of epiglottitis during large-scale vaccination with Haemophilus influenzae type B conjugate vaccine among children in Finland. Laryngoscope. 1994 Jun;104(6 Pt 1):731–735. doi: 10.1288/00005537-199406000-00013. [DOI] [PubMed] [Google Scholar]
  22. Teppo L., Pukkala E., Lehtonen M. Data quality and quality control of a population-based cancer registry. Experience in Finland. Acta Oncol. 1994;33(4):365–369. doi: 10.3109/02841869409098430. [DOI] [PubMed] [Google Scholar]

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