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British Journal of Cancer logoLink to British Journal of Cancer
letter
. 2001 Sep;85(6):898–901. doi: 10.1054/bjoc.2001.2002

DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2

S Narayan 1, A S Jaiswal 1, A S Multani 2, S Pathak 2,3
PMCID: PMC2375064  PMID: 11556843

Abstract

Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: DNA damage, p53, telomere, TRF1, TRF2, cell cycle arrest, apoptosis

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