Skip to main content
NCBI home page
Transactions of the American Clinical and Climatological Association logoLink to Transactions of the American Clinical and Climatological Association
. 1993;104:198–213.

Rheumatoid factors from patients with rheumatoid arthritis react with beta 2-microglobulin.

R C Williams Jr 1, C C Malone 1, N Tsuchiya 1
PMCID: PMC2376609  PMID: 1285310

Full text

PDF
198

Images in this article

199Fig. 1(A)
on p.199
200Fig. 1(B)
on p.200

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen J. C., Kunkel H. G. Hidden rheumatoid factors with specificity for native gamma globulins. Arthritis Rheum. 1966 Dec;9(6):758–768. doi: 10.1002/art.1780090603. [DOI] [PubMed] [Google Scholar]
  2. Chen P. P., Robbins D. L., Jirik F. R., Kipps T. J., Carson D. A. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. J Exp Med. 1987 Dec 1;166(6):1900–1905. doi: 10.1084/jem.166.6.1900. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cunningham B. A., Wang J. L., Berggård I., Peterson P. A. The complete amino acid sequence of beta 2-microglobulin. Biochemistry. 1973 Nov 20;12(24):4811–4822. doi: 10.1021/bi00748a001. [DOI] [PubMed] [Google Scholar]
  4. FRANKLIN E. C., HOLMAN H. R., MULLER-EBERHARD H. J., KUNKEL H. G. An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis. J Exp Med. 1957 May 1;105(5):425–438. doi: 10.1084/jem.105.5.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Getzoff E. D., Geysen H. M., Rodda S. J., Alexander H., Tainer J. A., Lerner R. A. Mechanisms of antibody binding to a protein. Science. 1987 Mar 6;235(4793):1191–1196. doi: 10.1126/science.3823879. [DOI] [PubMed] [Google Scholar]
  6. Geysen H. M., Rodda S. J., Mason T. J., Tribbick G., Schoofs P. G. Strategies for epitope analysis using peptide synthesis. J Immunol Methods. 1987 Sep 24;102(2):259–274. doi: 10.1016/0022-1759(87)90085-8. [DOI] [PubMed] [Google Scholar]
  7. Hunkapiller T., Hood L. Diversity of the immunoglobulin gene superfamily. Adv Immunol. 1989;44:1–63. doi: 10.1016/s0065-2776(08)60639-2. [DOI] [PubMed] [Google Scholar]
  8. KUNKEL H. G., FRANKLIN E. C., MULLER-EBERHARD H. J. Studies on the isolation and characterization of the "rheumatoid factor". J Clin Invest. 1959 Feb;38(2):424–434. doi: 10.1172/JCI103817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nardella F. A., Teller D. C., Barber C. V., Mannik M. IgG rheumatoid factors and staphylococcal protein A bind to a common molecular site on IgG. J Exp Med. 1985 Dec 1;162(6):1811–1824. doi: 10.1084/jem.162.6.1811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Natvig J. B., Gaarder P. I., Turner M. W. IgG antigens of the C gamma 2 and C gamma 3 homology regions interacting with rheumatoid factors. Clin Exp Immunol. 1972 Oct;12(2):177–184. [PMC free article] [PubMed] [Google Scholar]
  11. Orr H. T., Lancet D., Robb R. J., Lopez de Castro J. A., Strominger J. L. The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. Nature. 1979 Nov 15;282(5736):266–270. doi: 10.1038/282266a0. [DOI] [PubMed] [Google Scholar]
  12. Peterson P. A., Cunningham B. A., Berggård I., Edelman G. M. 2 -Microglobulin--a free immunoglobulin domain. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1697–1701. doi: 10.1073/pnas.69.7.1697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Saper M. A., Bjorkman P. J., Wiley D. C. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol. 1991 May 20;219(2):277–319. doi: 10.1016/0022-2836(91)90567-p. [DOI] [PubMed] [Google Scholar]
  14. Sasso E. H., Barber C. V., Nardella F. A., Yount W. J., Mannik M. Antigenic specificities of human monoclonal and polyclonal IgM rheumatoid factors. The C gamma 2-C gamma 3 interface region contains the major determinants. J Immunol. 1988 May 1;140(9):3098–3107. [PubMed] [Google Scholar]
  15. Smithies O., Poulik M. D. Initiation of protein synthesis at an unusual position in an immunoglobulin gene? Science. 1972 Jan 14;175(4018):187–189. doi: 10.1126/science.175.4018.187. [DOI] [PubMed] [Google Scholar]
  16. Stage D. E., Mannik M. Rheumatoid factors in rheumatoid arthritis. Bull Rheum Dis. 1972;23(7):720–725. [PubMed] [Google Scholar]
  17. Tanimoto K., Cooper N. R., Johnson J. S., Vaughan J. H. Complement fixation by rheumatoid factor. J Clin Invest. 1975 Mar;55(3):437–445. doi: 10.1172/JCI107949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Williams R. C., Jr, Kievit E., Tsuchiya N., Malone C., Hutt-Fletcher L. Differential mapping of Fc gamma-binding and monoclonal antibody-reactive epitopes on gE, the Fc gamma-binding glycoprotein of herpes simplex virus type 1. J Immunol. 1992 Oct 1;149(7):2415–2427. [PubMed] [Google Scholar]
  19. Williams R. C., Jr, Malone C. C., Casali P. Heteroclitic polyclonal and monoclonal anti-Gm(a) and anti-Gm(g) human rheumatoid factors react with epitopes induced in Gm(a-), Gm(g-) IgG by interaction with antigen or by nonspecific aggregation. A possible mechanism for the in vivo generation of rheumatoid factors. J Immunol. 1992 Sep 1;149(5):1817–1824. [PMC free article] [PubMed] [Google Scholar]
  20. Williams R. C., Jr, Malone C. C., Tsuchiya N. Rheumatoid factors from patients with rheumatoid arthritis react with beta 2-microglobulin. J Immunol. 1992 Aug 1;149(3):1104–1113. [PubMed] [Google Scholar]
  21. Williams R. C., Jr Symposium on the immunodiagnosis of rheumatic and related diseases, Part II. Rheumatoid factors. Hum Pathol. 1983 May;14(5):386–391. doi: 10.1016/s0046-8177(83)80282-2. [DOI] [PubMed] [Google Scholar]
  22. Zvaifler N. J., Schur P. Reactions of aggregated mercaptoethanol treated gamma globulin with rheumatoid factor--precipitin and complement fixation studies. Arthritis Rheum. 1968 Aug;11(4):523–536. doi: 10.1002/art.1780110402. [DOI] [PubMed] [Google Scholar]

Articles from Transactions of the American Clinical and Climatological Association are provided here courtesy of American Clinical and Climatological Association

RESOURCES