Abstract
The clinical application of Tc-99m Sestamibi imaging in acute myocardial infarction should be most useful. The capability of assessing risk area during acute coronary occlusion and degree of myocardial salvage after reperfusion offers a noninvasive means to assess the benefit of therapeutic interventions aimed at reducing myocardial ischemic injury. Further studies in larger numbers of patients appear warranted to identify the precise worth of this new imaging technique relative to other existing noninvasive imaging methodologies in clinical practice.
Full text
PDF










Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- De Coster P. M., Melin J. A., Detry J. M., Brasseur L. A., Beckers C., Col J. Coronary artery reperfusion in acute myocardial infarction: assessment by pre- and postintervention thallium-201 myocardial perfusion imaging. Am J Cardiol. 1985 Apr 1;55(8):889–895. doi: 10.1016/0002-9149(85)90712-x. [DOI] [PubMed] [Google Scholar]
- Gibbons R. J., Verani M. S., Behrenbeck T., Pellikka P. A., O'Connor M. K., Mahmarian J. J., Chesebro J. H., Wackers F. J. Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation. 1989 Nov;80(5):1277–1286. doi: 10.1161/01.cir.80.5.1277. [DOI] [PubMed] [Google Scholar]
- Okada R. D., Glover D., Gaffney T., Williams S. Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation. 1988 Feb;77(2):491–498. doi: 10.1161/01.cir.77.2.491. [DOI] [PubMed] [Google Scholar]
- Reduto L. A., Freund G. C., Gaeta J. M., Smalling R. W., Lewis B., Gould K. L. Coronary artery reperfusion in acute myocardial infarction: beneficial effects of intracoronary streptokinase on left ventricular salvage and performance. Am Heart J. 1981 Dec;102(6 Pt 2):1168–1177. doi: 10.1016/0002-8703(81)90648-7. [DOI] [PubMed] [Google Scholar]
- Sinusas A. J., Trautman K. A., Bergin J. D., Watson D. D., Ruiz M., Smith W. H., Beller G. A. Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile. Circulation. 1990 Oct;82(4):1424–1437. doi: 10.1161/01.cir.82.4.1424. [DOI] [PubMed] [Google Scholar]
- Sinusas A. J., Watson D. D., Cannon J. M., Jr, Beller G. A. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. J Am Coll Cardiol. 1989 Dec;14(7):1785–1793. doi: 10.1016/0735-1097(89)90034-x. [DOI] [PubMed] [Google Scholar]
- Wackers F. J., Berman D. S., Maddahi J., Watson D. D., Beller G. A., Strauss H. W., Boucher C. A., Picard M., Holman B. L., Fridrich R. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med. 1989 Mar;30(3):301–311. [PubMed] [Google Scholar]
- Wackers F. J., Gibbons R. J., Verani M. S., Kayden D. S., Pellikka P. A., Behrenbeck T., Mahmarian J. J., Zaret B. L. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: efficacy for noninvasive assessment of thrombolytic therapy. J Am Coll Cardiol. 1989 Oct;14(4):861–873. doi: 10.1016/0735-1097(89)90456-7. [DOI] [PubMed] [Google Scholar]

