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. 1993 Jun;67(6):3653–3655. doi: 10.1128/jvi.67.6.3653-3655.1993

The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.

M J Farrell 1, J M Hill 1, T P Margolis 1, J G Stevens 1, E K Wagner 1, L T Feldman 1
PMCID: PMC237719  PMID: 8388517

Abstract

The latency-associated transcription unit has been shown to be important for in vivo reactivation of herpes simplex virus from the latent state. A recombinant virus was constructed to alter the largest open reading frame in this region. This virus had a wild-type reactivation phenotype, suggesting that herpes simplex virus does not require a protein function from this reading frame for efficient reactivation from latency.

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Selected References

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