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. 1993 Jun;67(6):3680–3683. doi: 10.1128/jvi.67.6.3680-3683.1993

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.

T M Kündig 1, I Castelmur 1, M F Bachmann 1, D Abraham 1, D Binder 1, H Hengartner 1, R M Zinkernagel 1
PMCID: PMC237725  PMID: 7684471

Abstract

Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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