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. 1993 Jun;67(6):3680–3683. doi: 10.1128/jvi.67.6.3680-3683.1993

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.

T M Kündig 1, I Castelmur 1, M F Bachmann 1, D Abraham 1, D Binder 1, H Hengartner 1, R M Zinkernagel 1
PMCID: PMC237725  PMID: 7684471

Abstract

Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binder D., Kündig T. M. Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL. J Immunol. 1991 Jun 15;146(12):4301–4307. [PubMed] [Google Scholar]
  2. Blanden R. V. T cell response to viral and bacterial infection. Transplant Rev. 1974;19(0):56–88. doi: 10.1111/j.1600-065x.1974.tb00128.x. [DOI] [PubMed] [Google Scholar]
  3. Charan S., Hengartner H., Zinkernagel R. M. Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies. J Virol. 1987 Aug;61(8):2509–2514. doi: 10.1128/jvi.61.8.2509-2514.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Charan S., Zinkernagel R. M. Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus. J Immunol. 1986 Apr 15;136(8):3057–3061. [PubMed] [Google Scholar]
  5. Cobbold S. P., Jayasuriya A., Nash A., Prospero T. D., Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature. 1984 Dec 6;312(5994):548–551. doi: 10.1038/312548a0. [DOI] [PubMed] [Google Scholar]
  6. Hale A. H., Witte O. N., Baltimore D., Eisen H. N. Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1978 Feb;75(2):970–974. doi: 10.1073/pnas.75.2.970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Leist T. P., Cobbold S. P., Waldmann H., Aguet M., Zinkernagel R. M. Functional analysis of T lymphocyte subsets in antiviral host defense. J Immunol. 1987 Apr 1;138(7):2278–2281. [PubMed] [Google Scholar]
  8. Mackett M., Yilma T., Rose J. K., Moss B. Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle. Science. 1985 Jan 25;227(4685):433–435. doi: 10.1126/science.2981435. [DOI] [PubMed] [Google Scholar]
  9. Puddington L., Bevan M. J., Rose J. K., Lefrançois L. N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells. J Virol. 1986 Nov;60(2):708–717. doi: 10.1128/jvi.60.2.708-717.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Roost H., Charan S., Gobet R., Rüedi E., Hengartner H., Althage A., Zinkernagel R. M. An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus. Eur J Immunol. 1988 Apr;18(4):511–518. doi: 10.1002/eji.1830180404. [DOI] [PubMed] [Google Scholar]
  11. Rosenthal K. L., Zinkernagel R. M. Cross-reactive cytotoxic T cells to serologically distinct vesicular stomatitis virus. J Immunol. 1980 May;124(5):2301–2308. [PubMed] [Google Scholar]
  12. Rosenthal K. L., Zinkernagel R. M. Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk. J Immunol. 1981 Feb;126(2):446–451. [PubMed] [Google Scholar]
  13. Sethi K. K., Brandis H. The role of vesicular stomatitis virus major glycoprotein in determining the specificity of virus-specific and H-2-restricted cytolytic T cells. Eur J Immunol. 1980 Apr;10(4):268–272. doi: 10.1002/eji.1830100409. [DOI] [PubMed] [Google Scholar]
  14. Yewdell J. W., Bennink J. R., Mackett M., Lefrancois L., Lyles D. S., Moss B. Recognition of cloned vesicular stomatitis virus internal and external gene products by cytotoxic T lymphocytes. J Exp Med. 1986 Jun 1;163(6):1529–1538. doi: 10.1084/jem.163.6.1529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Zinkernagel R. M., Adler B., Holland J. J. Cell-mediated immunity to vesicular stomatitis virus infections in mice. Exp Cell Biol. 1978;46(1-2):53–70. doi: 10.1159/000162882. [DOI] [PubMed] [Google Scholar]
  16. Zinkernagel R. M., Althage A., Holland J. Target antigens for H-2-restricted vesicular stomatitis virus-specific cytotoxic T cells. J Immunol. 1978 Aug;121(2):744–748. [PubMed] [Google Scholar]
  17. Zinkernagel R. M., Cooper S., Chambers J., Lazzarini R. A., Hengartner H., Arnheiter H. Virus-induced autoantibody response to a transgenic viral antigen. Nature. 1990 May 3;345(6270):68–71. doi: 10.1038/345068a0. [DOI] [PubMed] [Google Scholar]

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