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. 1993 Jun;67(6):3696–3701. doi: 10.1128/jvi.67.6.3696-3701.1993

Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.

G Borisova 1, B Arya 1, A Dislers 1, O Borschukova 1, V Tsibinogin 1, D Skrastina 1, M A Eldarov 1, P Pumpens 1, K G Skryabin 1, E Grens 1
PMCID: PMC237728  PMID: 7684473

Abstract

A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.

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Selected References

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