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. 1993 Jul;67(7):4182–4189. doi: 10.1128/jvi.67.7.4182-4189.1993

Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.

M N Wykes 1, G R Shellam 1, J McCluskey 1, W M Kast 1, P B Dallas 1, P Price 1
PMCID: PMC237787  PMID: 8389923

Abstract

The expression of stable, correctly folded major histocompatibility complex class I molecules conferred susceptibility to murine cytomegalovirus (MCMV) in cells which were previously resistant to infection, demonstrating that these molecules interact critically with MCMV to initiate infection. All class I molecules could potentiate MCMV infection but H-2Dd and Kb molecules were most efficient. Monoclonal antibodies specific for the alpha 1 and/or alpha 2 domains of Dd and Kb inhibited infection. Infection of L cells transfected with hybrid major histocompatibility complex class I molecules demonstrated that allelic control of susceptibility to MCMV mapped to the alpha 1 domain of Dd when in correct configuration with the alpha 2 and alpha 3 domains. In MCMV-resistant RMA-S cells, an improvement in the conformation of class I molecules introduced susceptibility to infection.

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Selected References

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