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. 1993 Aug;67(8):4497–4503. doi: 10.1128/jvi.67.8.4497-4503.1993

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.

A P Poon 1, B Roizman 1
PMCID: PMC237833  PMID: 8331721

Abstract

The UL15 gene of herpes simplex virus 1 consists of two exons and is highly conserved among the herpesviruses sequenced to date. Other than its homology to a phage protein involved in the packaging of DNA, nothing is known of its function. This report concerns the isolation of a temperature-sensitive mutant with a mutation mapping in the UL15 open reading frame. Cells infected with the parent, mutant, and rescued viruses all make DNA at the nonpermissive temperature. Direct analyses of the DNA and electron microscopic studies indicate that although viral DNA is made, it is not packaged into capsids present in nuclei. These studies suggest that UL15 may be involved in the packaging of viral DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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