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. 1993 Feb;39:336–340.

Chronic fatigue syndrome. A fresh look at an old problem.

J McSherry 1
PMCID: PMC2379748  PMID: 8495124

Abstract

Chronic fatigue syndrome (CFS), an organic disease of unexplained origin, affects about three people in 100,000. Symptoms last approximately 2 1/2 years, and most CFS patients return to normal health. Diagnosis of CFS is by exclusion. No single remedy has yet proven consistently beneficial. Family physicians can help by providing medical validation of disability to persons who might otherwise be seen as malingerers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACHESON E. D. The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia. Am J Med. 1959 Apr;26(4):569–595. doi: 10.1016/0002-9343(59)90280-3. [DOI] [PubMed] [Google Scholar]
  2. Behan P. O., Behan W. M., Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990 Sep;82(3):209–216. doi: 10.1111/j.1600-0404.1990.tb04490.x. [DOI] [PubMed] [Google Scholar]
  3. Buchwald D., Sullivan J. L., Komaroff A. L. Frequency of 'chronic active Epstein-Barr virus infection' in a general medical practice. JAMA. 1987 May 1;257(17):2303–2307. [PubMed] [Google Scholar]
  4. Butler S., Chalder T., Ron M., Wessely S. Cognitive behaviour therapy in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry. 1991 Feb;54(2):153–158. doi: 10.1136/jnnp.54.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gold D., Bowden R., Sixbey J., Riggs R., Katon W. J., Ashley R., Obrigewitch R. M., Corey L. Chronic fatigue. A prospective clinical and virologic study. JAMA. 1990 Jul 4;264(1):48–53. doi: 10.1001/jama.264.1.48. [DOI] [PubMed] [Google Scholar]
  6. Goldenberg D. L. Fibromyalgia syndrome. An emerging but controversial condition. JAMA. 1987 May 22;257(20):2782–2787. doi: 10.1001/jama.257.20.2782. [DOI] [PubMed] [Google Scholar]
  7. Gow J. W., Behan W. M., Clements G. B., Woodall C., Riding M., Behan P. O. Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome. BMJ. 1991 Mar 23;302(6778):692–696. doi: 10.1136/bmj.302.6778.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Herpin D., Conte D. Assessment of the antihypertensive effect of lisinopril using 24-hour ambulatory monitoring. J Hum Hypertens. 1989 Jun;3 (Suppl 1):11–15. [PubMed] [Google Scholar]
  9. Holmes G. P., Kaplan J. E., Gantz N. M., Komaroff A. L., Schonberger L. B., Straus S. E., Jones J. F., Dubois R. E., Cunningham-Rundles C., Pahwa S. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988 Mar;108(3):387–389. doi: 10.7326/0003-4819-108-3-387. [DOI] [PubMed] [Google Scholar]
  10. Kaslow J. E., Rucker L., Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989 Nov;149(11):2501–2503. [PubMed] [Google Scholar]
  11. Kroenke K., Wood D. R., Mangelsdorff A. D., Meier N. J., Powell J. B. Chronic fatigue in primary care. Prevalence, patient characteristics, and outcome. JAMA. 1988 Aug 19;260(7):929–934. [PubMed] [Google Scholar]
  12. Lloyd A., Hickie I., Wakefield D., Boughton C., Dwyer J. A double-blind, placebo-controlled trial of intravenous immunoglobulin therapy in patients with chronic fatigue syndrome. Am J Med. 1990 Nov;89(5):561–568. doi: 10.1016/0002-9343(90)90173-b. [DOI] [PubMed] [Google Scholar]
  13. Manu P., Lane T. J., Matthews D. A. The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med. 1988 Oct 1;109(7):554–556. doi: 10.7326/0003-4819-109-7-554. [DOI] [PubMed] [Google Scholar]
  14. Peterson P. K., Shepard J., Macres M., Schenck C., Crosson J., Rechtman D., Lurie N. A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Am J Med. 1990 Nov;89(5):554–560. doi: 10.1016/0002-9343(90)90172-a. [DOI] [PubMed] [Google Scholar]
  15. Salit I. E. Sporadic postinfectious neuromyasthenia. CMAJ. 1985 Oct 1;133(7):659–663. [PMC free article] [PubMed] [Google Scholar]
  16. Straus S. E., Dale J. K., Tobi M., Lawley T., Preble O., Blaese R. M., Hallahan C., Henle W. Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. N Engl J Med. 1988 Dec 29;319(26):1692–1698. doi: 10.1056/NEJM198812293192602. [DOI] [PubMed] [Google Scholar]
  17. Straus S. E., Tosato G., Armstrong G., Lawley T., Preble O. T., Henle W., Davey R., Pearson G., Epstein J., Brus I. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med. 1985 Jan;102(1):7–16. doi: 10.7326/0003-4819-102-1-7. [DOI] [PubMed] [Google Scholar]
  18. Wessely S., Powell R. Fatigue syndromes: a comparison of chronic "postviral" fatigue with neuromuscular and affective disorders. J Neurol Neurosurg Psychiatry. 1989 Aug;52(8):940–948. doi: 10.1136/jnnp.52.8.940. [DOI] [PMC free article] [PubMed] [Google Scholar]

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