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. 1993 Oct;67(10):6270–6272. doi: 10.1128/jvi.67.10.6270-6272.1993

Congo red inhibition of scrapie agent replication.

B Caughey 1, D Ernst 1, R E Race 1
PMCID: PMC238051  PMID: 8103804

Abstract

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

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Selected References

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