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. 1993 Oct;67(10):6317–6321. doi: 10.1128/jvi.67.10.6317-6321.1993

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.

K R Berend 1, J U Jung 1, T J Boyle 1, J M DiMaio 1, S A Mungal 1, R C Desrosiers 1, H K Lyerly 1
PMCID: PMC238060  PMID: 8396687

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

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Selected References

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