Abstract
Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERG G., CLARKE N. A., KABLER P. W. Interrelationships among ECHO virus types 1,8, and 12. J Bacteriol. 1962 Mar;83:556–560. doi: 10.1128/jb.83.3.556-560.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bergelson J. M., Chan B. M., Finberg R. W., Hemler M. E. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest. 1993 Jul;92(1):232–239. doi: 10.1172/JCI116555. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bergelson J. M., Shepley M. P., Chan B. M., Hemler M. E., Finberg R. W. Identification of the integrin VLA-2 as a receptor for echovirus 1. Science. 1992 Mar 27;255(5052):1718–1720. doi: 10.1126/science.1553561. [DOI] [PubMed] [Google Scholar]
- Giancotti F. G., Ruoslahti E. Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell. 1990 Mar 9;60(5):849–859. doi: 10.1016/0092-8674(90)90098-y. [DOI] [PubMed] [Google Scholar]
- Harris L. F., Haynes R. E., Cramblett H. G., Conant R. M., Jenkins G. R. Antigenic analysis of echoviruses 1 and 8. J Infect Dis. 1973 Jan;127(1):63–68. doi: 10.1093/infdis/127.1.63. [DOI] [PubMed] [Google Scholar]
- Hemler M. E., Ware C. F., Strominger J. L. Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J Immunol. 1983 Jul;131(1):334–340. [PubMed] [Google Scholar]
- Mbida A. D., Gaudin O. G., Sabido O., Pozzetto B., Le Bihan J. C. Monoclonal antibody specific for the cellular receptor of echoviruses. Intervirology. 1992;33(1):17–22. doi: 10.1159/000150226. [DOI] [PubMed] [Google Scholar]
- Mbida A. D., Pozzetto B., Gaudin O. G., Grattard F., Le Bihan J. C., Akono Y., Ros A. A 44,000 glycoprotein is involved in the attachment of echovirus-11 onto susceptible cells. Virology. 1992 Jul;189(1):350–353. doi: 10.1016/0042-6822(92)90714-z. [DOI] [PubMed] [Google Scholar]
- Mbida A. D., Pozzetto B., Sabido O., Akono Y., Grattard F., Habib M., Gaudin O. G. Competition binding studies with biotinylated echovirus 11 in cytofluorimetry analysis. J Virol Methods. 1991 Nov-Dec;35(2):169–176. doi: 10.1016/0166-0934(91)90132-j. [DOI] [PubMed] [Google Scholar]
- Shepley M. P., Sherry B., Weiner H. L. Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7743–7747. doi: 10.1073/pnas.85.20.7743. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sherry B., Rueckert R. Evidence for at least two dominant neutralization antigens on human rhinovirus 14. J Virol. 1985 Jan;53(1):137–143. doi: 10.1128/jvi.53.1.137-143.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takada Y., Hemler M. E. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul;109(1):397–407. doi: 10.1083/jcb.109.1.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Urlaub G., Chasin L. A. Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4216–4220. doi: 10.1073/pnas.77.7.4216. [DOI] [PMC free article] [PubMed] [Google Scholar]