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. 1992 Jan;66(1):580–585. doi: 10.1128/jvi.66.1.580-585.1992

Human colon epithelial cells productively infected with human immunodeficiency virus show impaired differentiation and altered secretion.

J Fantini 1, N Yahi 1, S Baghdiguian 1, J C Chermann 1
PMCID: PMC238320  PMID: 1727501

Abstract

Selected strains of the human immunodeficiency virus (HIV) types 1 and 2 are able to infect human colon epithelial cells in vitro, suggesting a mechanism for the anal route of HIV transmission. In some cases, HIV is not produced by infected colon cells but can be rescued after coculture with T-lymphoid cells. One of the HIV strains (HIV1-NDK) replicated well in colonic cells. A transmission electron microscope study demonstrated two major structural perturbations in producer colon cells: an unusual number of secretion bodies and the appearance of intracellular lumina with disorganized microvilli, indicating a defect in brush border assembly and differentiation. Either abnormality could account for HIV-induced enteropathy consisting of chronic diarrhea and malabsorption in the absence of enteric pathogens. Moreover, HT29 cells infected with HIV provide a unique model for selection of enterotropic HIV strains.

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Selected References

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