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. 1980 Feb;26:225-227, 229-230.

Pulmonary Histoplasmosis: A Review of 50 Cases

Chandra Bilgi
PMCID: PMC2383443  PMID: 21293595

Abstract

Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum. Infection, identified by skin testing, has been found in more than 50 countries. In Canada the disease is endemic in the St. Lawrence River Valley. Fifty patients with positive reaction to histoplasmin skin tests were reviewed at the Provincial Chest Clinic in Windsor, Ontario. All were asymptomatic; 27 had a history of present or previous involvement in farming or poultry rearing.

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Selected References

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  1. BAUM G. L., SCHWARZ J. Pulmonary histoplasmosis. N Engl J Med. 1958 Apr 3;258(14):677–684. doi: 10.1056/NEJM195804032581402. [DOI] [PubMed] [Google Scholar]
  2. BAUM G. L., SCHWARZ J. The history of histoplasmosis, 1906 to 1956. N Engl J Med. 1957 Feb 7;256(6):253–258. doi: 10.1056/NEJM195702072560605. [DOI] [PubMed] [Google Scholar]
  3. BILLINGS F. T., Jr, COUCH O. A., Jr Pericardial calcification and histoplasmin sensitivity. Ann Intern Med. 1955 Mar;42(3):654–658. doi: 10.7326/0003-4819-42-3-654. [DOI] [PubMed] [Google Scholar]
  4. Bilgi C., Slesar S. Letter: Constrictive pericarditis and pericardial calcification with positive histoplasmin skin test. Can Med Assoc J. 1976 May 22;114(10):877–882. [PMC free article] [PubMed] [Google Scholar]
  5. Brodsky A. L., Gregg M. B., Loewenstein M. S., Kaufman L., Mallison G. F. Outbreak of histoplasmosis associated with the 1970 Earth Day activities. Am J Med. 1973 Mar;54(3):333–342. doi: 10.1016/0002-9343(73)90028-4. [DOI] [PubMed] [Google Scholar]
  6. CHRISTIE A. The disease spectrum of human histoplasmosis. Trans Assoc Am Physicians. 1951;64:147–154. [PubMed] [Google Scholar]
  7. CONRAD F. G., SASLAW S., ATWELL R. J. The protean manifestations of histoplasmosis as illustrated in twenty-three cases. Arch Intern Med. 1959 Nov;104:692–709. doi: 10.1001/archinte.1959.00270110012003. [DOI] [PubMed] [Google Scholar]
  8. CURRY F. J., WIER J. A. Histoplasmosis: a review of one hundred consecutively hospitalized patients. Am Rev Tuberc. 1958 May;77(5):749–763. doi: 10.1164/artpd.1958.77.5.749. [DOI] [PubMed] [Google Scholar]
  9. Christie A., Peterson J. C. Pulmonary Calcification in Negative Reactors to Tuberculin. Am J Public Health Nations Health. 1945 Nov;35(11):1131–1147. doi: 10.2105/ajph.35.11.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Course and prognosis of untreated histoplasmogis. A United States Public Health Service Cooperative Mycoses Study. JAMA. 1961 Aug 5;177:292–296. [PubMed] [Google Scholar]
  11. DODGE H. J., AJELLO L., ENGELKE O. K. THE ASSOCIATION OF A BIRD-ROOSTING SITE WITH INFECTION OF SCHOOL CHILDREN BY HISTOPLASMA CAPSULATUM. Am J Public Health Nations Health. 1965 Aug;55:1203–1211. doi: 10.2105/ajph.55.8.1203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. EDWARDS P. Q., KLAER J. H. Worldwide geographic distribution of histoplasmosis and histoplasmin sensitivity. Am J Trop Med Hyg. 1956 Mar;5(2):235–257. [PubMed] [Google Scholar]
  13. FURCOLOW M. L., BRASHER C. A. Chronic progressive (cavitary) histoplasmosis as a problem in tuberculosis sanatoriums. Am Rev Tuberc. 1956 May;73(5):609–619. doi: 10.1164/artpd.1956.73.5.609. [DOI] [PubMed] [Google Scholar]
  14. FURCOLOW M. L. Tests of immunity in histoplasmosis. N Engl J Med. 1963 Feb 14;268:357–361. doi: 10.1056/NEJM196302142680706. [DOI] [PubMed] [Google Scholar]
  15. HEYN R. M., GIAMMONA S. T. Disseminated histoplasmosis treated with amphotericin B. AMA J Dis Child. 1959 Aug;98(2):253–256. doi: 10.1001/archpedi.1959.02070020255012. [DOI] [PubMed] [Google Scholar]
  16. Kaufman L., Terry R. T., Schubert J. H., McLaughlin D. Effects of a single histoplasmin skin test on the serological diagnosis of histoplasmosis. J Bacteriol. 1967 Oct;94(4):798–803. doi: 10.1128/jb.94.4.798-803.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LEHAN P. H., FURCOLOW M. L. Epidemic histoplasmosis. J Chronic Dis. 1957 Apr;5(4):489–503. doi: 10.1016/0021-9681(57)90117-0. [DOI] [PubMed] [Google Scholar]
  18. LOOSLI C. G., PROCKNOW J. J., TANZI F., GRAYSTON J. T., COMBS L. W. Pulmonary histoplasmosis in a farm family; a three-year follow-up. J Lab Clin Med. 1954 May;43(5):669–695. [PubMed] [Google Scholar]
  19. PUCKETT T. F. Pulmonary histoplasmosis; a study of twenty-two cases with identification of H. capsulatum in resected lesions. Am Rev Tuberc. 1953 Apr;67(4):453–476. doi: 10.1164/art.1953.67.4.453. [DOI] [PubMed] [Google Scholar]
  20. Picardi J. L., Kauffman C. A., Schwarz J., Holmes J. C., Phair J. P., Fowler N. O. Pericarditis caused by Histoplasma capsulatum. Am J Cardiol. 1976 Jan;37(1):82–88. doi: 10.1016/0002-9149(76)90504-x. [DOI] [PubMed] [Google Scholar]
  21. RUBIN H., LEHAN P. H., FURCOLOW M. L. Severe nonfatal histoplasmosis; report of a typical case, with comments on therapy. N Engl J Med. 1957 Sep 26;257(13):599–602. doi: 10.1056/NEJM195709262571304. [DOI] [PubMed] [Google Scholar]
  22. Reddy P., Gorelick D. F., Brasher C. A., Larsh H. Progressive disseminated histoplasmosis as seen in adults. Am J Med. 1970 May;48(5):629–636. doi: 10.1016/0002-9343(70)90014-8. [DOI] [PubMed] [Google Scholar]
  23. SCHWARZ J., SILVERMAN F. N., ADRIANO S. M., STRAUB M., LEVINE S. The relation of splenic calcification to histoplasmosis. N Engl J Med. 1955 May 26;252(21):887–891. doi: 10.1056/NEJM195505262522102. [DOI] [PubMed] [Google Scholar]
  24. SILVERMAN F. N., SCHWARZ J., LAHEY M. E., CARSON R. P. Histoplasmosis. Am J Med. 1955 Sep;19(3):410–459. doi: 10.1016/0002-9343(55)90129-7. [DOI] [PubMed] [Google Scholar]
  25. STRAUB M., SCHWARZ J. The healed primary complex in histoplasmosis. Am J Clin Pathol. 1955 Jul;25(7):727–741. doi: 10.1093/ajcp/25.7.727. [DOI] [PubMed] [Google Scholar]
  26. Sarosi G. A., Voth D. W., Dahl B. A., Doto I. L., Tosh F. E. Disseminated histoplasmosis: results of long-term follow-up. A center for disease control cooperative mycoses study. Ann Intern Med. 1971 Oct;75(4):511–516. doi: 10.7326/0003-4819-75-4-511. [DOI] [PubMed] [Google Scholar]
  27. Smith J. W., Utz J. P. Progressive disseminated histoplasmosis. A prospective study of 26 patients. Ann Intern Med. 1972 Apr;76(4):557–565. doi: 10.7326/0003-4819-76-4-557. [DOI] [PubMed] [Google Scholar]
  28. TOSH F. E., BALHUIZEN J., YATES J. L., BRASHER C. A. PRIMARY CUTANEOUS HISTOPLASMOSIS. REPORT OF A CASE. Arch Intern Med. 1964 Jul;114:118–119. doi: 10.1001/archinte.1964.03860070164022. [DOI] [PubMed] [Google Scholar]
  29. The current status of serologic, immunologic and skin tests in the diagnosis of pulmonary mycoses. Report of the Committee on Fungus Diseases and Subcommittee on Criteria for Clinical Diagnosis--American College of Chest Physicians. Chest. 1973 Feb;63(2):259–270. [PubMed] [Google Scholar]
  30. Vanek J., Schwarz J. The gamut of histoplasmosis. Am J Med. 1971 Jan;50(1):89–104. doi: 10.1016/0002-9343(71)90208-7. [DOI] [PubMed] [Google Scholar]
  31. WHITEHOUSE W. M., DAVEY W. N., ENGELKE O. K., HOLT J. F. Roentgen findings in histoplasmin-positive school children. J Mich State Med Soc. 1959 Aug;58:1266–1269. [PubMed] [Google Scholar]
  32. WILCOX K. R., Jr, WAISBREN B. A., MARTIN J. The Walworth, Wisconsin, epidemic of histoplasmosis. Ann Intern Med. 1958 Aug;49(2):388–418. doi: 10.7326/0003-4819-49-2-388. [DOI] [PubMed] [Google Scholar]

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