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. 1985 Jan;49(1):250–252. doi: 10.1128/aem.49.1.250-252.1985

Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.

G Corthier, F Dubos, P Raibaud
PMCID: PMC238383  PMID: 3977313

Abstract

Gnotobiotic mice died 2 days after inoculation of a cytotoxigenic Clostridium difficile strain. Protection occurred when mice were previously inoculated with a strain of Escherichia coli or Bifidobacterium bifidum. Intestinal cytotoxin production was highly reduced in the surviving mice, whereas the C. difficile population level did not decrease to a great extent.

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Selected References

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