Abstract
Orally administered diacetoxyscirpenol (2 mg/kg of body weight) was rapidly absorbed into the blood serum of pigs; within 1 h, the highest amounts of diacetoxyscirpenol (9.6 to 21.9 ng/ml) were detected. Two metabolites of diacetoxyscirpenol were identified by gas chromatography-mass spectroscopy as monoacetoxyscirpenol and scirpenetriol. The three trichothecenes were present in the blood serum of pigs for only 24 h, indicating a rapid metabolism of these compounds.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chi M. S., Mirocha C. J. Necrotic oral lesions in chickens fed diacetoxyscirpenol, T-2 toxin, and crotocin. Poult Sci. 1978 May;57(3):807–808. doi: 10.3382/ps.0570807. [DOI] [PubMed] [Google Scholar]
- Côté L. M., Reynolds J. D., Vesonder R. F., Buck W. B., Swanson S. P., Coffey R. T., Brown D. C. Survey of vomitoxin-contaminated feed grains in midwestern United States, and associated health problems in swine. J Am Vet Med Assoc. 1984 Jan 15;184(2):189–192. [PubMed] [Google Scholar]
- Ghosal S., Biswas K., Srivastava R. S., Chakrabarti D. K., Chaudhary K. C. Toxic substances produced by Fusarium V: occurrence of zearalenone, diacetoxyscirpenol, and T-2 toxin in moldy corn infected with Fusarium moniliforme Sheld. J Pharm Sci. 1978 Dec;67(12):1768–1769. doi: 10.1002/jps.2600671238. [DOI] [PubMed] [Google Scholar]
- Grove J. F., Mortimer P. H. The cytotoxicity of some transformation products of diacetoxyscirpenol. Biochem Pharmacol. 1969 Jun;18(6):1473–1478. doi: 10.1016/0006-2952(69)90261-5. [DOI] [PubMed] [Google Scholar]
- Ishii K., Pathre S. V., Mirocha C. J. Two new trichothecenes produced by Fusarium roseum. J Agric Food Chem. 1978 May-Jun;26(3):649–653. doi: 10.1021/jf60217a030. [DOI] [PubMed] [Google Scholar]
- Jemmali M., Ueno Y., Ishii K., Frayssinet C., Etienne M. Natural occurrence of trichothecenes (nivalenol, deoxynivalenol, T2) and zearalenone in corn. Experientia. 1978 Oct 15;34(10):1333–1334. doi: 10.1007/BF01981454. [DOI] [PubMed] [Google Scholar]
- Matsumoto H., Ito T., Ueno Y. Toxicological approaches to the metabolities of fusaria. XII. Fate and distribution of T-2 toxin in mice. Jpn J Exp Med. 1978 Oct;48(5):393–399. [PubMed] [Google Scholar]
- Mirocha C. J., Pathre S. V., Schauerhamer B., Christensen C. M. Natural occurrence of Fusarium toxins in feedstuff. Appl Environ Microbiol. 1976 Oct;32(4):553–556. doi: 10.1128/aem.32.4.553-556.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ohta M., Matsumoto H., Ishii K., Ueno Y. Metabolism of trichothecene mycotoxins. II. Substrate specificity of microsomal deacetylation of trichothecenes. J Biochem. 1978 Sep;84(3):697–706. doi: 10.1093/oxfordjournals.jbchem.a132175. [DOI] [PubMed] [Google Scholar]
- Pathre S. V., Mirocha C. J., Christensen C. M., Behrens J. Monoacetoxyscirpenol. A new mycotoxin produced by Fusarium roseum Gibbosum. J Agric Food Chem. 1976 Jan-Feb;24(1):97–103. doi: 10.1021/jf60203a053. [DOI] [PubMed] [Google Scholar]
- Robison T. S., Mirocha C. J., Kurtz H. J., Behrens J. C., Weaver G. A., Chi M. S. Distribution of tritium-labeled T-2 toxin in swine. J Agric Food Chem. 1979 Nov-Dec;27(6):1411–1413. doi: 10.1021/jf60226a022. [DOI] [PubMed] [Google Scholar]
- Siegfried R. Fusarium-Toxine. Naturwissenschaften. 1977 May;64(5):274–274. doi: 10.1007/BF00438309. [DOI] [PubMed] [Google Scholar]
- Swanson S. P., Terwel L., Corley R. A., Buck W. B. Gas chromatographic method for the determination of diacetoxyscirpenol in swine plasma and urine. J Chromatogr. 1982 Oct 29;248(3):456–460. doi: 10.1016/s0021-9673(00)85057-8. [DOI] [PubMed] [Google Scholar]
- Ueno Y., Sato N., Ishii K., Sakai K., Tsunoda H. Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol. 1973 Apr;25(4):699–704. doi: 10.1128/am.25.4.699-704.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weaver G. A., Kurtz H. J., Mirocha C. J., Bates F. Y., Behrens J. C. Acute toxicity of the mycotoxin diacetoxyscirpenol in swine. Can Vet J. 1978 Oct;19(10):267–271. [PMC free article] [PubMed] [Google Scholar]
- Yoshizawa T., Mirocha C. J., Behrens J. C., Swanson S. P. Metabolic fate of T-2 toxin in a lactating cow. Food Cosmet Toxicol. 1981 Feb;19(1):31–39. doi: 10.1016/0015-6264(81)90300-x. [DOI] [PubMed] [Google Scholar]
- Yoshizawa T., Swanson S. P., Mirocha C. J. T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin. Appl Environ Microbiol. 1980 Jun;39(6):1172–1177. doi: 10.1128/aem.39.6.1172-1177.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]