Abstract
Gas chromatography-mass spectrometry was used to identify various T-2 toxin metabolites in chicken excreta and organs 18 h after intraperitoneal injection of the toxin. No trichothecenes were detected in the heart and kidneys, and only trace amounts were detected in the lungs. Most of the T-2 metabolites were found in the excreta, although considerable amounts were also found in the liver. In addition to the previously identified T-2 metabolites in chicken excreta (HT-2 toxin, 15 acetoxy T-2 tetraol, and T-2 tetraol), we found 3'-hydroxy HT-2 toxin (the major metabolite in excreta and organs), 3'-hydroxy T-2 toxin, 4-acetoxy T-2 tetraol, and trace amounts of 8-acetoxy T-2 tetraol, 3-acetoxy-3'hydroxy HT-2 toxin, and T-2 triol. Unmetabolized T-2 toxin and an unidentified isomer of T-2 tetraol monoacetate were also detected in the excreta. Most of the metabolites in the chicken are similar to those encountered in cultures of fungal species producing T-2 toxin. A comparison with T-2 toxin metabolism in the cow is also reported.
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- Chi M. S., Robison T. S., Mirocha C. J., Reddy K. R. Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks. Appl Environ Microbiol. 1978 Apr;35(4):636–640. doi: 10.1128/aem.35.4.636-640.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chi M. S., Robison T. S., Mirocha C. J., Swanson S. P., Shimoda W. Excretion and tissue distribution of radioactivity from tritium-labeled T-2 toxin in chicks. Toxicol Appl Pharmacol. 1978 Aug;45(2):391–402. doi: 10.1016/0041-008x(78)90103-5. [DOI] [PubMed] [Google Scholar]
- Matsumoto H., Ito T., Ueno Y. Toxicological approaches to the metabolities of fusaria. XII. Fate and distribution of T-2 toxin in mice. Jpn J Exp Med. 1978 Oct;48(5):393–399. [PubMed] [Google Scholar]
- Robison T. S., Mirocha C. J., Kurtz H. J., Behrens J. C., Weaver G. A., Chi M. S. Distribution of tritium-labeled T-2 toxin in swine. J Agric Food Chem. 1979 Nov-Dec;27(6):1411–1413. doi: 10.1021/jf60226a022. [DOI] [PubMed] [Google Scholar]
- Yoshizawa T., Mirocha C. J., Behrens J. C., Swanson S. P. Metabolic fate of T-2 toxin in a lactating cow. Food Cosmet Toxicol. 1981 Feb;19(1):31–39. doi: 10.1016/0015-6264(81)90300-x. [DOI] [PubMed] [Google Scholar]
- Yoshizawa T., Swanson S. P., Mirocha C. J. T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin. Appl Environ Microbiol. 1980 Jun;39(6):1172–1177. doi: 10.1128/aem.39.6.1172-1177.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]