Abstract
The effects of positively charged nylon and depth (cellulose-diatomaceous earth) filters on endotoxin removal from various solutions were evaluated. The charged filter media removed significant amounts of Escherichia coli and natural endotoxin from tap water, distilled water, sugars, and NaCl solutions; no significant removal of endotoxin was observed with negatively charged filter media. The extent of removal was influenced by pH, the presence of salts, and organic matter. Such media may be useful for the control of endotoxins in raw-product water or solutions used to prepare parenteral drug products or in other fluids where endotoxin control is desired.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Haskå G., Nystrand R. Determination of endotoxins in sugar with the Limulus test. Appl Environ Microbiol. 1979 Dec;38(6):1078–1080. doi: 10.1128/aem.38.6.1078-1080.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hou K., Gerba C. P., Goyal S. M., Zerda K. S. Capture of latex beads, bacteria, endotoxin, and viruses by charge-modified filters. Appl Environ Microbiol. 1980 Nov;40(5):892–896. doi: 10.1128/aem.40.5.892-896.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaden H. Zur Anwendung von Asbestfilterschichten bei der Herstellung steriler und pyrogenfreier Lösungen. Pharmazie. 1975 Nov;30(11):752–753. [PubMed] [Google Scholar]
- Keleti G., Sykora J. L. Production and properties of cyanobacterial endotoxins. Appl Environ Microbiol. 1982 Jan;43(1):104–109. doi: 10.1128/aem.43.1.104-109.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maitra S. K., Yoshikawa T. T., Guze L. B., Schotz M. C. Properties of binding of Escherichia coli endotoxin to various matrices. J Clin Microbiol. 1981 Jan;13(1):49–53. doi: 10.1128/jcm.13.1.49-53.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sweadner K. J., Forte M., Nelsen L. L. Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation. Appl Environ Microbiol. 1977 Oct;34(4):382–385. doi: 10.1128/aem.34.4.382-385.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]