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. 1985 Dec;50(6):1509–1511. doi: 10.1128/aem.50.6.1509-1511.1985

Studies on the sensitivity and specificity of the Limulus amebocyte lysate test and rabbit pyrogen assays.

M J Devleeschouwer, M F Cornil, J Dony
PMCID: PMC238789  PMID: 3911908

Abstract

The sensitivity and specificity of the Limulus amebocyte lysate test and rabbit pyrogen assay were studied by means of artificially contaminated parenterals. Various gram-negative and gram-positive bacterial strains were used as was one strain of the yeast Candida albicans. The numbers of organisms needed to elicit positive responses in distilled water and normal saline were recorded and compared. The sensitivity and specificity of the Limulus amebocyte lysate assay for the detection of bacterial endotoxin from gram-negative bacteria were demonstrated. Variable results were recorded with gram-positive bacteria and Candida albicans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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