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. 1983 Jul;46(1):120–127. doi: 10.1128/aem.46.1.120-127.1983

Metabolism of T-2 toxin in Curtobacterium sp. strain 114-2.

Y Ueno, K Nakayama, K Ishii, F Tashiro, Y Minoda, T Omori, K Komagata
PMCID: PMC239276  PMID: 6614901

Abstract

The metabolic pathway of T-2 toxin in Curtobacterium sp. strain 114, one of the T-2 toxin-assimilating soil bacteria, was investigated by thin-layer and gas-liquid chromatographic analyses. T-2 toxin added to the basal medium as a single carbon and energy source was biotransformed into HT-2 toxin and an unknown metabolite. Infrared, mass spectrum, proton magnetic resonance, and other physico-chemical analyses identified this new metabolite as T-2 triol. T-2 toxin was first deacetylated by the bacterium into HT-2 toxin, and this metabolite was then biotransformed into T-2 triol without formation of neosolaniol and T-2 tetraol. No trichothecenes remained in the culture medium after prolonged culture. Some properties of T-2 toxin-hydrolyzing enzymes were observed with whole cells, the cell-free soluble fraction, and the culture filtrate. Besides T-2 toxin, trichothecenes such as diacetoxyscirpenol, neosolaniol, nivalenol, and fusarenon-X were also assimilated by this bacterium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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