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. 1990;68(Suppl):126–131.

Hepatic phase of malaria: a crucial role as "go-between" with other stages.

D Mazier 1, J Goma 1, S Pied 1, L Renia 1, A Nussler 1, F Miltgen 1, D Mattei 1, G Grau 1
PMCID: PMC2393019  PMID: 2151269

Abstract

Besides potential interest in itself, the hepatic stage of malaria might play a crucial role as "go-between" with other stages. When present in the parasitophorous vacuole, antibodies induced by both sporozoite and erythrocytic stages efficiently disturb hepatic development of the parasite. Likewise previous and ensuing erythrocytic stages can modulate the "shielded" phase by cytokines, directly or as a result of a cascade of events, and by MHC-restricted or antibody-dependent cytotoxic mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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