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. 1990;68(Suppl):94–98.

An invariant, "universal" T-cell epitope in the P. falciparum circumsporozoite protein.

F Sinigaglia 1, M Guttinger 1, H Matile 1, J R Pink 1
PMCID: PMC2393022  PMID: 1709837

Abstract

Although there are important obstacles to malaria vaccine development, we believe they might be overcome by a strategy of searching for conserved regions of a vaccine candidate that are recognized in association with many different HLA molecules and, if necessary, deliberately modifying the conserved sequences to improve their immunogenicity for T cells. This approach is illustrated by work on the circumsporozoite (CS) protein of Plasmodium falciparum, which covers the surface of the malaria sporozoite and is the best characterized of current vaccine candidates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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