Skip to main content
NCBI home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1992;70(1):85–91.

Early immunization of neonates with trivalent oral poliovirus vaccine.

L Y Weckx 1, B J Schmidt 1, A A Herrmann 1, C H Miyasaki 1, N F Novo 1
PMCID: PMC2393354  PMID: 1314711

Abstract

Described is the evaluation in Brazil of the immune response of early immunization with trivalent oral poliovirus vaccine (TOPV). A total of 85 normal neonates from São Paulo were assigned one of the following immunization schedules: group A--one dose of TOPV at birth and subsequent doses at 2, 4, and 9 months of age; or group B--one dose of TOPV at 2, 4 and 6 months of age. Blood samples were collected sequentially from the mother at delivery, from the umbilical cord, and from the child at 2, 4, 6, 9 and 12 months of age for assay of poliovirus neutralizing antibodies. Administration of TOPV at birth, in addition to establishing immunity against poliomyelitis at an earlier stage, produced a superior immune response to poliovirus type 3. At the end of the first year, the proportion of susceptible individuals was 3.7% in group A and 25.9% in group B. When immunization against poliomyelitis is started at birth, excellent seroconversion rates are obtained from the third dose onward.

Full text

PDF
85

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dong D. X., Hu X. M., Liu W. J., Li J. S., Jin Y. C., Tan S. G., Chen T. Q., Fu J. Z., Niu B. Y., Yu H. M. Immunization of neonates with trivalent oral poliomyelitis vaccine (Sabin). Bull World Health Organ. 1986;64(6):853–860. [PMC free article] [PubMed] [Google Scholar]
  2. EBERS D. W., GIBBS G. E., SMITH D. I. Gastric acidity on the first day of life. Pediatrics. 1956 Nov;18(5):800–802. [PubMed] [Google Scholar]
  3. FELDMAN R. A., HOLGUIN A. H., GELFAND H. M. ORAL POLIOVIRUS VACCINATION IN CHILDREN: A STUDY SUGGESTING ENTEROVIRUS INTERFERENCE. Pediatrics. 1964 Apr;33:526–533. [PubMed] [Google Scholar]
  4. Halsey N., Galazka A. The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age. Bull World Health Organ. 1985;63(6):1151–1169. [PMC free article] [PubMed] [Google Scholar]
  5. Idris M. Z., Mathur A., Sharma P., Chaturvedi U. C., Sharma N. L. Oral polio vaccination and factors affecting its efficacy. Indian J Med Res. 1980 May;71:671–678. [PubMed] [Google Scholar]
  6. John T. J. Antibody response of infants in tropics to five doses of oral polio vaccine. Br Med J. 1976 Apr 3;1(6013):812–812. doi: 10.1136/bmj.1.6013.812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. John T. J., Jayabal P. Oral polio vaccination of children in the tropics. I. The poor seroconversion rates and the absence of viral interference. Am J Epidemiol. 1972 Oct;96(4):263–269. doi: 10.1093/oxfordjournals.aje.a121457. [DOI] [PubMed] [Google Scholar]
  8. KRUGMAN S., WARREN J., EIGER M. S., BERMAN P. H., MICHAELS R. M., SABIN A. B. Immunization with live attenuated poliovirus vaccine. Am J Dis Child. 1961 Jan;101:23–29. doi: 10.1001/archpedi.1961.04020020025005. [DOI] [PubMed] [Google Scholar]
  9. Katz M., Brown R. E., Plotkin S. A. Oral poliovirus vaccination in newborn African infants: relative ineffectiveness of early feeding of vaccine. Trop Geogr Med. 1968 Jun;20(2):133–136. [PubMed] [Google Scholar]
  10. Keller R., Dwyer J. E., Oh W., D'Amodio M. Intestinal IgA neutralizing antibodies in newborn infants following poliovirus immunization. Pediatrics. 1969 Mar;43(3):330–338. [PubMed] [Google Scholar]
  11. LEPOW M. L., WARREN R. J., GRAY N., INGRAM V. G., ROBBINS F. C. Effect of Sabin Type 1 poliomyelitis vaccine administered by mouth to newborn infants. N Engl J Med. 1961 May 25;264:1071–1078. doi: 10.1056/NEJM196105252642102. [DOI] [PubMed] [Google Scholar]
  12. MOSCOVICI C., MAISEL J. Intestinal viruses of newborn and older prematures. Am J Dis Child. 1961 Jun;101:771–777. doi: 10.1001/archpedi.1961.04020070085012. [DOI] [PubMed] [Google Scholar]
  13. Melnick J. L., Burkhardt M., Taber L. H., Erckman P. N. Developing gap in immunity to poliomyelitis in an urban area. JAMA. 1969 Aug 25;209(8):1181–1185. [PubMed] [Google Scholar]
  14. Neves W. E., Rodrigues M. C., Kipnis J., Carvalho R. P., Amato Neto V. Vacinaço antipoliomeilîtica, tipo Sabin, em crianças com um e três meses de idade. Rev Inst Med Trop Sao Paulo. 1968 Nov-Dec;10(6):376–382. [PubMed] [Google Scholar]
  15. PAGANO J. S., PLOTKIN S. A., KOPROWSKI H. Variations in the responses of infants to living attenuated poliovirus vaccines. N Engl J Med. 1961 Jan 26;264:155–163. doi: 10.1056/NEJM196101262640401. [DOI] [PubMed] [Google Scholar]
  16. PLOTKIN S. A., KOPROWSKI H., STOKES J., Jr Clinical trials in infants of orally administered attenuated poliomyelitis viruses. Pediatrics. 1959 Jun;23(6):1041–1062. [PubMed] [Google Scholar]
  17. Patriarca P. A., Laender F., Palmeira G., Oliveira M. J., Lima Filho J., Dantes M. C., Cordeiro M. T., Risi J. B., Jr, Orenstein W. A. Randomised trial of alternative formulations of oral poliovaccine in Brazil. Lancet. 1988 Feb 27;1(8583):429–433. doi: 10.1016/s0140-6736(88)91229-9. [DOI] [PubMed] [Google Scholar]
  18. Plotkin S. A., Katz M., Brown R. E., Pagano J. S. Oral poliovirus vaccination in newborn African infants. The inhibitory effect of breast feeding. Am J Dis Child. 1966 Jan;111(1):27–30. doi: 10.1001/archpedi.1966.02090040063004. [DOI] [PubMed] [Google Scholar]
  19. ROSENBAUM M. J., PHILLIPS I. A., SULLIVAN E. J., EDWARDS E. A., MILLER L. F. A simplified method for virus-tissue culture procedures in microtitration plates. Proc Soc Exp Biol Med. 1963 May;113:224–229. doi: 10.3181/00379727-113-28325. [DOI] [PubMed] [Google Scholar]
  20. SABIN A. B., MICHAELS R. H., ZIRING P., KRUGMAN S., WARREN J. Effect of oral poliovirus vaccine in newborn children. II. Intestinal resistance and antibody response at 6 months in children fed type I vaccine at birth. Pediatrics. 1963 Apr;31:641–650. [PubMed] [Google Scholar]
  21. STEIGMAN A. J., LIPTON M. M. Neonatal immunity. II. Poliocidal effects of human amniotic fluids. Proc Soc Exp Biol Med. 1958 Dec;99(3):576–579. doi: 10.3181/00379727-99-24425. [DOI] [PubMed] [Google Scholar]
  22. Schatzmayr H. G., Maurice Y., Fujita M., de Fillipis A. M. Serological evaluation of poliomyelitis oral and inactivated vaccines in an urban low-income population at Rio de Janeiro, Brazil. Vaccine. 1986 Jun;4(2):111–113. doi: 10.1016/0264-410x(86)90048-4. [DOI] [PubMed] [Google Scholar]
  23. Sokhey J., Gupta C. K., Sharma B., Singh H. Stability of oral polio vaccine at different temperatures. Vaccine. 1988 Feb;6(1):12–13. doi: 10.1016/0264-410x(88)90006-0. [DOI] [PubMed] [Google Scholar]
  24. Waldman E. A., Fujita M., Hutzler R. U., Ferrari F. L., Ayub M. A., Pinto P. R., Matheus J. G., Kim J. S., Cury P. C. Ocorrência de infecço por enterovírus em recém-nascidos internados em maternidade no município de São Paulo, Brasil (1980). Rev Inst Med Trop Sao Paulo. 1984 Jan-Feb;26(1):7–12. doi: 10.1590/s0036-46651984000100002. [DOI] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES