Abstract
The Nigerian Expanded Programme on Immunization (EPI) was assessed with particular reference to measles immunization. Of 150 children who received measles vaccine at the Institute of Child Health, University of Ibadan, Nigeria, 82 (54.7%) seroconverted. The immune response was directly related to the titre of the vaccines used. Vaccines whose titres were 10(-1) to 10(1.7) stimulated immune responses in 0-25% of vaccinees, those with titres in the range 10(-2.1) to 10(-2.5) stimulated responses in 12-47.6%, while those with titres of 10(-2.7) to 10(-3.4) stimulated responses in 87.5-100% of vaccinees. Only one of the vaccines used had a titre that met the minimum WHO required standard of log 10(-3) TCID50 at the point of vaccination.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abdurrahman M. B., Greenwood B. M., Olafimihan O., Whitle H. C. Measles antibody levels from birth to 9 months of age in Nigerian infants. Afr J Med Med Sci. 1982 Sep;11(3):113–115. [PubMed] [Google Scholar]
- Albrecht P., Ennis F. A., Saltzman E. J., Krugman S. Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure. J Pediatr. 1977 Nov;91(5):715–718. doi: 10.1016/s0022-3476(77)81021-4. [DOI] [PubMed] [Google Scholar]
- Munube G. M. Measles sero-immunity in rural non-vaccinated children of Busoga District, Uganda. East Afr Med J. 1979 Jul;56(7):335–338. [PubMed] [Google Scholar]
- Nakano J. H., Miller D. L., Foster S. O., Brink E. W. Microtiter determination of measles hemagglutination inhibition antibody with filter papers. J Clin Microbiol. 1983 May;17(5):860–863. doi: 10.1128/jcm.17.5.860-863.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]